Natural History of Cirrhosis: Changing Trends in Etiology Over the Years
Yazarlar (15)
Ramazan Idilman Ankara Üniversitesi, Türkiye
Dr. Öğr. Üyesi Merve AYDOĞAN Ankara Üniversitesi, Türkiye
Mehmet Berk Oruncu
Ankara Üniversitesi, Türkiye
Ankara Üniversitesi, Türkiye
Aysun Kartal Ankara Üniversitesi, Türkiye
Atilla Halil Elhan Ankara Üniversitesi, Türkiye
Zeynep Ellik
Ankara Üniversitesi, Türkiye
Ankara Üniversitesi, Türkiye
Mesut Gumussoy Ankara Üniversitesi, Türkiye
Ramazan Er
Ankara Üniversitesi, Türkiye
Ankara Üniversitesi, Türkiye
Mubin Ozercan
Ankara Üniversitesi, Türkiye
Ankara Üniversitesi, Türkiye
Serkan Duman
Ankara Üniversitesi, Türkiye
Ankara Üniversitesi, Türkiye
Murat Toruner Ankara Üniversitesi, Türkiye
Kubilay Cinar Ankara Üniversitesi, Türkiye
Irfan Soykan
Ankara Üniversitesi, Türkiye
Ankara Üniversitesi, Türkiye
Ali Resit Beyler
Ankara Üniversitesi, Türkiye
Ankara Üniversitesi, Türkiye
Hasan Ozkan
Ankara Üniversitesi, Türkiye
Ankara Üniversitesi, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | Digestive Diseases (Q3) | ||
| Dergi ISSN | 0257-2753 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | Türkçe | Basım Tarihi | 11-2020 |
| Cilt / Sayı / Sayfa | 39 / 4 / 358–365 | DOI | 10.1159/000512746 |
| Makale Linki | https://doi.org/10.1159/000512746 | ||
| Özet |
Background and goalsThe aims of the present study were to investigate the natural history of cirrhosis and to determine trends in the etiology of cirrhosis.MethodsBetween January 2001 and January 2018, a total of 1341 patients had been diagnosed with cirrhosis were included.ResultsA total of 898 cirrhotic patients, who were followed for at least six months were included into the analysis. The median age was 54 years. The median Child-Pugh and MELD scores were 7.5 and 11, respectively. Ascites (51%) was the most common causes of decompensation. Chronic viral hepatitis was the most frequent cause of cirrhosis (58%). Hepatitis B virus (HBV) infection was the main etiology (34%), followed by hepatitis C virus (HCV) infection (18%). Among 129 patients with cryptogenic cirrhosis (CC), 60 had metabolic abnormalities. If these 60 patients with CC were considered to have non-alcoholic fatty liver disease (NAFLD)-related cirrhosis, the proportion of NAFLD-related cirrhosis increased from 1.8% to 8.0%. At admission, 74 patients (8%) had been diagnosed with hepatocellular carcinoma (HCC). A new HCC developed in 80 patients during the follow-up period. The probability of developing HCC was 3.9% at 12 months. Logistic regression analysis showed that the development of HCC was significantly associated with older age (p<0.001), male gender (p<0.001), viral etiology (p=0.026) and baseline high aspartate aminotransferase level (p=0.01). Overall, 104 cirrhotic patients died.In conclusionHBV and HCV remain the leading causes of etiology in cirrhosis and HCC. However, NAFLD-related cirrhosis is recognized is recognized as a growing burden. |
| Anahtar Kelimeler |
| Cirrhosis | Hepatitis B virus | Hepatitis C virus | Hepatocellular carcinoma | Nonalcoholic fatty liver disease | Nonalcoholic steatohepatitis |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Scopus | 16 |
| Web of Science | 18 |