Synthesis, biological evaluation and molecular docking studies of new 2-ethoxy-4-{[3-alkyl (aryl)-4, 5-dihydro-1H-1, 2, 4-triazol-5-on-4-yl]-azomethine}-phenyl benzenesulfonate …
Yazarlar (1)
Doç. Dr. Murat BEYTUR Kafkas Üniversitesi, Türkiye
| Makale Türü |
Özgün Makale
(Uluslararası alan indekslerindeki dergilerde yayınlanan tam makale)
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| Dergi Adı | Beilstein Archives | ||
| Makale Dili | – | Basım Tarihi | 04-2021 |
| Cilt / Sayı / Sayfa | 2021 / 1 / 31–0 | DOI | – |
| Makale Linki | https://www.beilstein-journals.org/xiv/download/pdf/202131-pdf | ||
| UAK Araştırma Alanları |
Organik Kimya
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| Özet |
| Staphylococcus aureus, Bacillus subtilis, Bacillus cereus and Klepsiella pneumonia according to agar well diffusion method. Furthermore, in order to determine the possible antidiabetic properties of the synthesized 1, 2, 4-triazole derivatives, inhibition effects on the AR enzyme were investigated and molecular docking studies were carried out to determine the receptorligand interactions of these compounds. IC50 values of triazole-derived compounds (6a, 6b, 6d-g) against AR enzyme were determined as 0.95 µM, 0.75 µM, 1.83 µM, 0.62 µM, 1.05 µM, 1.06 µM, respectively. Considering the docking scores and binding energies obtained docking studies, it has been shown that molecules fit very well to the active site of the AR enzyme. |
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