Synthesis, biological evaluation and molecular docking studies of new 2-ethoxy-4-{[3-alkyl (aryl)-4, 5-dihydro-1H-1, 2, 4-triazol-5-on-4-yl]-azomethine}-phenyl benzenesulfonate …
Yazarlar (1)
Prof. Dr. Muzaffer ALKAN Kafkas Üniversitesi, Türkiye
| Makale Türü | Özgün Makale (Uluslararası alan indekslerindeki dergilerde yayınlanan tam makale) | ||
| Dergi Adı | Beilstein Archives | ||
| Makale Dili | – | Basım Tarihi | 04-2021 |
| Cilt / Sayı / Sayfa | 2021 / 1 / 31–0 | DOI | – |
| Makale Linki | https://www.beilstein-journals.org/xiv/preprints/202131 | ||
| UAK Araştırma Alanları |
Fen Bilgisi Eğitimi
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| Özet |
| A series of 2-ethoxy-4-{[3-alkyl (aryl)-4, 5-dihydro-1H-1, 2, 4-triazol-5-on-4-yl]-azomethine}-phenyl benzenesulfonates (3) were synthesized from the reactions of 3-alkyl (aryl)-4-amino-4, 5-dihydro-1H-1, 2, 4-triazol-5-ones (1) with 2-ethoxy-4-formyl-phenyl benzenesulfonate (2). N-acetyl derivatives (4) of compounds 3 were also obtained. Then, the compounds 3 have been treated with morpholine and 2, 6-dimethylmorpholine in the presence of formaldehyde to synthesize 2-ethoxy-4-{[1-(morpholine-4-yl-methyl)-3-alkyl (aryl)-4, 5-dihydro-1H-1, 2, 4-triazol-5-on-4-yl]-azomethine}-phenyl benzenesulfonates (5) and 2-ethoxy-4-{[1-(2, 6-dimethylmorpholine-4-yl-methyl)-3-alkyl (aryl)-4, 5-dihydro-1H-1, 2, 4-triazol-5-on-4-yl]-azomethine}-phenyl benzenesulfonates (6), respectively. The structures of twenty-six new compounds were identified by using elemental analysis, IR, 1 H NMR, 13 C NMR, and MS spectral data. In … |
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