Antioxidant and Antimicrobial Activities of Some Newly Synthesized 4-[1-(2, 6-Dimethylmorpholin-4-yl-methyl)-3-alkyl (aryl)-4, 5-dihydro-1H-1, 2, 4-triazol-5-on-4-yl-azomethine …
Yazarlar (1)
Prof. Dr. Muzaffer ALKAN Kafkas Üniversitesi, Türkiye
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Özgün Makale
(Uluslararası alan indekslerindeki dergilerde yayınlanan tam makale)
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| Dergi Adı | The Eurasia Proceedings of Science Technology Engineering and Mathematics | ||
| Makale Dili | – | Basım Tarihi | 08-2018 |
| Cilt / Sayı / Sayfa | 0 / 2 / 72–80 | DOI | – |
| Makale Linki | https://dergipark.org.tr/en/pub/epstem/article/454705 | ||
| UAK Araştırma Alanları |
Fen Bilgisi Eğitimi
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| Özet |
| In this study, 4-(3-alkyl/aryl-4,5-dihydro-1 H -1,2,4-triazol-5-one-4-yl-azomethine)-2-methoxyphenyl benzoates were treated with 2,6-dimethylmorpholine in the presence of formaldehyde according to the Mannich reaction to synthesize six novel 4-[1-(2,6-dimethylmorpholin-4-yl-methyl)-3-alkyl(aryl)-4,5-dihydro-triazol-5-on-4-yl-azomethine]-2-methoxyphenyl benzoates. The structures of synthesized six novel heterocyclic compounds were characterized by IR, 13 C-NMR and 1 H-NMR spectroscopic methods. The novel 4-[1-(2,6-dimethylmorpholin-4-yl-methyl)-3-alkyl(aryl)-4,5-dihydro-triazol-5-on-4-yl-azomethine]-2-methoxyphenyl benzoates were investigated in vitro antioxidant properties by using reducing power, free radical scavenging and metal chelating activity. For the measurement of the reductive ability, Fe 3+ -Fe 2+ transformation was investigated in the presence of compound using by the method of Oyaizu (1986). The hydrogen atoms or electrons donation ability of the synthesized compound was measured by DPPH . using the method of Blois (1958 ). The chelating effect of ferrous ions by the compound was determined according to the method of Dinis, Madeira & Almeida (1994 ). BHT, BHA, EDTA and α-tocopherol were used as reference antioxidant compounds. The new compounds were examined in-vitro antimicrobial properties against 6 different microorganisms ( Bacillus substilis (ATCC11774) , BacilluscCereus (ATCC11778) , Staphylococcus aureus (ATCC6538), Escherichia coli (ATCC25922) , Pseudomonas aeruginosa (ATCC27853) and Klebsiella pneumonia (ATCC4352)) by the agar well method and the obtained results … |
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