The effect of hyperthyroidism on the levels of Na+ K+ ATPase, glucose-6-phosphate dehydrogenase and glutathione.
Yazarlar (1)
Prof. Dr. Muzaffer ALKAN Kafkas Üniversitesi, Türkiye
Makale Türü Özgün Makale (Uluslararası alan indekslerindeki dergilerde yayınlanan tam makale)
Dergi Adı ISRAEL JOURNAL OF VETERINARY MEDICINE
Makale Dili – Basım Tarihi 06-2002
Cilt / Sayı / Sayfa 57 / 1 / 19–22 DOI 10.5555/20023072229
Makale Linki https://www.cabidigitallibrary.org/doi/full/10.5555/20023072229
UAK Araştırma Alanları
Fen Bilgisi Eğitimi
Özet
This study was carried out to investigate the effect of hyperthyroidism on the activity of Na+ K+ ATPase, glutathione (GSH) and glucose-6-P dehydrogenase (G6PD). Rabbits (n=16) were divided into two groups of 8: control and treatment. Treatment group was injected daily with L-tyrosine (MERCK) (100 µg/kg i.p., for 21 days). After the treatment, blood samples were collected into vacutaine tubes containing sodium heparin. Concentrations of plasma triiodothyronine (T3) and thyroxine (T4) were measured using DPC-Immulite kit. Na+ K+ ATPase activity in erythrocyte was determined colorimetrically by the release of inorganic phosphate from ATP in the presence and absence of oubain. The activities of GSH and G6PD were assayed spectrophotometrically. In the treatment group, Na+ K+ ATPase levels were decreased (P<0.05) while GSH and G6PD levels (P<0.05) were elevated compared to control values.
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The effect of hyperthyroidism on the levels of Na+ K+ ATPase, glucose-6-phosphate dehydrogenase and glutathione.