Serum malondialdehyde levels at admission as a predictor of inhospital mortality in patients with acute coronary syndrome
Yazarlar (11)
Doç. Dr. Muammer KARAKAYALI Kafkas Üniversitesi, Türkiye
Prof. Dr. Metin ÖĞÜN Kafkas Üniversitesi, Türkiye
Doç. Dr. İnanç ARTAÇ Kafkas Üniversitesi, Türkiye
Doç. Dr. Doğan İLİŞ Kafkas Üniversitesi, Türkiye
Doç. Dr. Ayça ARSLAN Kafkas Üniversitesi, Türkiye
Doç. Dr. Timor Omar Kafkas Üniversitesi, Türkiye
Arş. Gör. Öztürk DEMİR Kafkas Üniversitesi, Türkiye
Dr. Öğr. Üyesi Talha KARAHAN Kafkas Üniversitesi, Türkiye
Dr. Öğr. Üyesi Soner KINA Kafkas Üniversitesi, Türkiye
Prof. Dr. İbrahim RENCÜZOĞULLARI Kafkas Üniversitesi, Türkiye
Prof. Dr. Yavuz KARABAĞ Kafkas Üniversitesi, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | Coronary Artery Disease (Q3) | ||
| Dergi ISSN | 0954-6928 Dergi Bilgileri (2025) | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 05-2025 |
| Cilt / Sayı / Sayfa | 36 / 3 / 211–217 | DOI | 10.1097/MCA.0000000000001469 |
| Makale Linki | https://doi.org/10.1097/mca.0000000000001469 | ||
| UAK Araştırma Alanları |
Anesteziyoloji ve Reanimasyon
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| Özet |
| Malondialdehyde (MDA) is a predictive marker of cardiovascular events in patients with stable angina pectoris. However, there is limited information available regarding this marker in patients with acute coronary syndrome (ACS). The aim of the study was to explore the association of MDA levels with inhospital mortality among patients with ACS. The study sample consisted of 556 ACS patients. The leftover plasma samples collected in EDTA vials for troponin T estimation within 24 h of chest pain were used for analysis. Blood samples were collected into tubes for MDA, nitric oxide (NO), inducible nitric oxide synthase (i-NOS), endothelial nitric oxide synthase (e-NOS), total sialic acid (TSA), NT-proBNP, ANP, homocysteine, and cardiac troponin I (cTnI). The blood samples were centrifuged (4000 g , 4 °C) for 10 min, and the obtained serum then kept at -25 °C until the analyses were carried out. The relationship between these markers and inhospital mortality of ACS patients was investigated. Univariate logistic regression analysis revealed significant correlations among sex, age, creatine, MDA, NT-proBNP, ANP, homocysteine, cTnI, NO, e-NOS, i-NOS, and TSA. Further analysis of these variables using the multivariate logistic regression analysis indicated that age, creatine, MDA, and NT-proBNP were independent predictors. Optimal MDA cutoff value of >33.1 predicted inhospital mortality with 85% sensitivity and 88.17% specificity [AUC: 0.905 (95% CI: 0.878-0.928, P < 0.001)]. We demonstrated that MDA levels were elevated in cases of inhospital mortality among ACS patients and the optimal MDA cutoff value of >33.1 predicted inhospital mortality with 85% sensitivity and 88.17% specificity. |
| Anahtar Kelimeler |
| acute coronary syndrome | coronary artery disease | malondialdehyde | mortality |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Yöksis | 26 |
| Web of Science | 29 |