| Yazarlar |
Yakup Gültekin
Selçuk Üniversitesi, Türkiye |
|
Naile Öztürk
İnönü Üniversitesi, Türkiye |
|
Ayhan Filazi
Türkiye |
Prof. Dr. Ahmet DENİZ
Türkiye |
|
Çağla Korkmaz
Türkiye |
|
Esra Pezik
Türkiye |
|
Gözde Barın
Türkiye |
|
İmran Vural
Hacettepe Üniversitesi, Türkiye |
| Özet |
| A simple, rapid and reproducible HPLC method has been developed and validated for the quantification of albendazole sulfoxide (ALBSOX) and praziquantel (PRZ), which can coexist in various dosage forms. Chromatographic separation was performed in gradient mode using a mobile phase consisting of an InertSustain® C18 column (150 × 4.6 mm, 5 μm) and acetonitrile: water (v/v) at a flow rate of 1.0 mL/min. The active substance peaks were well separated and detected by a DAD detector at 217 nm. The HPLC method was linear for ALBSOX and PRZ in the concentration range of 0.1-50 μg/mL. Limit of detection (LOD) was found to be 0.01 μg/mL for ALBSOX and 0.009 μg/mL for PRZ. The limit of quantification (LOQ) was found to be 0.03 μg/mL for ALBSOX and 0.027 μg/mL for PRZ. The developed HPLC method was validated based on ICH guidelines for specificity, linearity, system suitability, precision and accuracy. The method was applied for simultaneous quantification and characterization studies of ALBSOX and PRA in PLGA nanoparticles. |
| Anahtar Kelimeler |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | ESCI dergilerinde yayımlanan tam makale |
| Dergi Adı | Journal of Research in Pharmacy |
| Dergi ISSN | 2630-6344 |
| Dergi Tarandığı Indeksler | ESCI |
| Makale Dili | İngilizce |
| Basım Tarihi | 07-2022 |
| Cilt No | 26 |
| Sayı | 6 |
| Sayfalar | 1608 / 1618 |
| Doi Numarası | 10.29228/jrp.252 |
| Makale Linki | http://dx.doi.org/10.29228/jrp.252 |
| Atıf Sayıları | |
| TRDizin | 1 |
