Immunohistochemical Evaluation of BRCA1 and BRCA2 Expressions in Dogs with Different Grades of Malignancy, Histological Subtypes and Metastatic/Non-Metastatic Mammary Gland Adenocarcinomas
Yazarlar (7)
Doç. Dr. Emin KARAKURT Kafkas Üniversitesi, Türkiye
Prof. Dr. Mushap KURU Kafkas Üniversitesi, Türkiye
Prof. Dr. Cihan KAÇAR Kafkas Üniversitesi, Türkiye
Prof. Dr. Enver BEYTUT Kafkas Üniversitesi, Türkiye
Prof. Dr. Semra KAYA Kafkas Üniversitesi, Türkiye
Dr. Öğr. Üyesi Murat Can DEMİR Kafkas Üniversitesi, Türkiye
Dr. Öğr. Üyesi Ayfer YILDIZ UYSAL Kafkas Üniversitesi, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | Pakistan Veterinary Journal (Q1) | ||
| Dergi ISSN | 0253-8318 Dergi Bilgileri (2026) | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 03-2026 |
| Cilt / Sayı / Sayfa | 46 / 2 / 392–400 | DOI | 10.29261/pakvetj/2026.028 |
| Makale Linki | https://www.pvj.com.pk/pdf-files/25-1116.pdf | ||
| UAK Araştırma Alanları |
Veteriner Patolojisi
|
||
| Özet |
| This study primarily aimed to examine BRCA1 and BRCA2 expression in various types of canine mammary gland adenocarcinomas using immunohistochemistry with the avidin-biotin-peroxidase Complex (ABC). The study material comprised adenocarcinoma samples obtained from the mammary glands of 20 dogs that were presented for routine histopathological examination at the Department of Pathology in the Faculty of Veterinary Medicine at Kafkas University between 2012 and 2022. The tumour masses had a highly haemorrhagic and ulcerative appearance. These round or oval-shaped masses were primarily greyish-white in colour. Especially in mixed-type carcinomas, tumour masses were particularly firm in consistency due to the presence of bone and cartilage components. 5 out of 20 cases (25%) were classified as mixed-type carcinoma, 4 out of 20 cases (20%) as tubular-type carcinoma, 4 out of 20 cases (20%) as solid-type carcinoma, 3 out of 20 cases (15%) as tubulopapillary-type carcinoma, 3 out of 20 cases (15%) as intraductal papillarytype carcinoma and 1 out of 20 cases (5%) as micropapillary-type carcinoma. 6 cases were classified as grade-1 malignancy (30%), 6 as grade 2 (30%), and the remaining 8 as grade 3 (40%). Metastatic tumour foci in the lung and lymph nodes were also confirmed by histopathology. No difference was observed between the degree of differentiation of secondary and primary tumour foci. BRCA1-and BRCA2-positive immunolabelling were predominantly concentrated in the cytoplasm of tumour cells. Compared to metastatic cases, the immunopositivity for the aforementioned biomarkers was … |
| Anahtar Kelimeler |
| BRCA | Canine Mammary Tumour | Malignancy Degree | Metastasis | Prognosis |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Web of Science | 1 |
| Scopus | 1 |
| Google Scholar | 1 |