Activation of TLR4/NF-κB/TNF-α pathway in inflammation and apoptosis during stable and progressive phases of canine transmissible venereal tumors
Yazarlar (10)
Doç. Dr. İsmail Bolat Atatürk Üniversitesi, Türkiye
Prof. Dr. Enver BEYTUT Kafkas Üniversitesi, Türkiye
Prof. Dr. Yavuz Selim Sağlam Atatürk Üniversitesi, Türkiye
Doç. Dr. Emin KARAKURT Kafkas Üniversitesi, Türkiye
Doç. Dr. Selim Çomaklı Atatürk Üniversitesi, Türkiye
Arş. Gör. Betül Orhan Atatürk Üniversitesi, Türkiye
Doç. Dr. Muhammet Bahaeddin Dörtbudak Harran Üniversitesi, Türkiye
Ahmet Melik Acar Kafkas Üniversitesi, Veteriner Fakültesi, Türkiye
Selda Güneş
Kafkas Üniversitesi, Veteriner Fakültesi, Türkiye
Kafkas Üniversitesi, Veteriner Fakültesi, Türkiye
Murat Çeğindir
Atatürk Üniversitesi, Türkiye
Atatürk Üniversitesi, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | Tissue and Cell (Q1) | ||
| Dergi ISSN | 0040-8166 Dergi Bilgileri (2026) | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 02-2026 |
| Cilt / Sayı / Sayfa | 98 / 1 / – | DOI | 10.1016/j.tice.2025.103193 |
| Makale Linki | https://www.sciencedirect.com/science/article/pii/S0040816625004756 | ||
| UAK Araştırma Alanları |
Veteriner Patolojisi
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| Özet |
| BackgroundCanine Transmissible Venereal Tumor (CTVT) is a clonally transmissible, low-grade malignant round-cell tumor that affects dogs of all ages and breeds. Although malignant due to its invasive potential and occasional metastasis, it differs from classical malignancies by its unique ability to undergo spontaneous regression, leading some authors to describe it as benign-like. CTVT progresses through progressive (P), stable (S), and regressive (R) phases. The P phase is characterized by rapid tumor proliferation, while the S phase shows arrested growth and unchanged lesions. Despite numerous studies, the molecular mechanisms underlying these transitions remain incompletely understood.AimThis study aimed to evaluate the role of the TLR4/NF-κB/TNF-α signaling pathway in the P and S phases of CTVT.MethodologyTumor samples from 12 CTVT-positive dogs were classified into P and S phases (n … |
| Anahtar Kelimeler |
| Apoptosis | Canine Transmissible Venereal Tumor | Inflammation | Progressive | Stable |
Science Direct
Activation of TLR4/NF-κB/TNF-α pathway in inflammation and apoptosis during stable and progressive phases of canine transmissible venereal tumors
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Google Scholar | 1 |