Maedi infection modulates oncogenic and inflammatory signaling in ovine pulmonary adenomatosis through TLR4/NF-κB and JAK2/STAT3 pathways: A Trojan horse mechanism
Yazarlar (10)
Doç. Dr. İsmail Bolat Atatürk Üniversitesi, Türkiye
Prof. Dr. Enver BEYTUT Kafkas Üniversitesi, Türkiye
Prof. Dr. Yavuz Selim Sağlam Atatürk Üniversitesi, Türkiye
Doç. Dr. Emin KARAKURT Kafkas Üniversitesi, Türkiye
Dr. Öğr. Üyesi Nüvit COŞKUN Kafkas Üniversitesi, Türkiye
Doç. Dr. Selim Çomaklı Atatürk Üniversitesi, Türkiye
Berrah Gözegir
Atatürk Üniversitesi, Türkiye
Atatürk Üniversitesi, Türkiye
Tuba Karaarslan
Atatürk Üniversitesi, Türkiye
Atatürk Üniversitesi, Türkiye
Dr. Öğr. Üyesi Merve Bolat Atatürk Üniversitesi, Türkiye
Arş. Gör. Betül Orhan Atatürk Üniversitesi, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | Veterinary Microbiology (Q1) | ||
| Dergi ISSN | 0378-1135 Dergi Bilgileri (2026) | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 03-2026 |
| Cilt / Sayı / Sayfa | 314 / 1 / – | DOI | 10.1016/j.vetmic.2026.110906 |
| Makale Linki | https://www.sciencedirect.com/science/article/pii/S0378113526000374?via%3Dihub | ||
| UAK Araştırma Alanları |
Veteriner Patolojisi
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| Özet |
| Ovine pulmonary adenomatosis (OPA) is a contagious pulmonary tumor of sheep caused by Jaagsiekte sheep retrovirus, whereas Maedi is a chronic lentiviral infection characterized by persistent pulmonary inflammation. Although both diseases affect the lung, their interaction during natural co-infection remains poorly understood. This study investigated how chronic Maedi infection may influence inflammatory, oncogenic, and apoptotic signaling pathways in OPA-affected lung tissue. Lung samples from naturally infected sheep were classified by PCR and histopathological examination into Maedi (n = 6), OPA (n = 6), and Maedi+OPA co-infection (n = 6) groups. Key inflammatory, oncogenic, and apoptotic markers were evaluated at the protein and transcript levels. Maedi and mixed infection groups showed increased activation of the TLR4/NF-κB pathway and elevated pro-inflammatory cytokine expression … |
| Anahtar Kelimeler |
| Apoptosis | Inflammation | JAK2/STAT3 | Maedi-Visna virus | Ovine pulmonary adenomatosis | TLR4/NF-κB |
Science Direct
Maedi infection modulates oncogenic and inflammatory signaling in ovine pulmonary adenomatosis through TLR4/NF-κB and JAK2/STAT3 pathways: A Trojan horse mechanism
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Web of Science | 1 |
| Scopus | 1 |
| Google Scholar | 2 |