Protective Effect of Silymarin on Diethylnitrosamine Induced Hepatocellular Carcinoma Model in Wistar Rats Cancer Patterns and Cytological Variants
Yazarlar (2)
Doç. Dr. Emin KARAKURT Kafkas Üniversitesi, Türkiye
Prof. Dr. Serpil DAĞ Kafkas Üniversitesi, Türkiye
| Makale Türü |
Özgün Makale
(SCOPUS dergilerinde yayınlanan tam makale)
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| Dergi Adı | Ataturk Universitesi Veteriner Bilimleri Dergisi | ||
| Dergi ISSN | 1306-6137 Scopus Dergi | ||
| Dergi Tarandığı Indeksler | ELSEVIER – Scopus, EBSCO, Cab Abstracts, CABI full text, ULAKBİM-TUBİTAK Yaşam Bilimleri, Türkiye Atıf Dizini, Google Scholar | ||
| Makale Dili | İngilizce | Basım Tarihi | 04-2020 |
| Cilt / Sayı / Sayfa | 15 / 1 / 43–50 | DOI | 10.17094/ATAUNIVBD.680945 |
| Makale Linki | https://dergipark.org.tr/tr/pub/ataunivbd/issue/54116/680945 | ||
| UAK Araştırma Alanları |
Veterinerlik Patolojisi
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| Özet |
| In this study, the protective effect of silymarin was investigated with histopathological methods in terms of cancer patterns and cytological variants in the hepatocellular carcinoma model created by applying diethylnitrosamine experimentally in rats. For this purpose, the rats were randomly divided into 5 groups. The rats in the control group were fed pellet feed and drinking water for 20 weeks. Animals in Sham group were administered with propylene glycol dissolved in 0.9% NaCl intraperitoneally 3 times a week for 20 weeks. Animals in DEN group administered DEN at a dose of 50 mg/kg once a week for 20 weeks. The rats in the DEN +Silymarin group were Silymarin intraperitoneally administered for 21 weeks 3 times a week at a dose of 100 mg/kg, starting 1 week prior to the administration of DEN. Silymarin was administered to rats in the group of Silymarin 3 times a week intraperitoneally for 20 weeks at a dose of 100 mg/kg. At the end of the study, systemic necropsy of the animals was performed and liver tissue samples were taken. After routine tissue procedures, sections were examined under the light microscope. We observed that Hepatocellular carcinoma occurred in DEN and DEN + Silymarin groups. |
| Anahtar Kelimeler |
| Diethylnitrosamine | Hepatocellular Carcinoma | Patterns | Silymarin | Variants |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Scopus | 3 |
| Google Scholar | 5 |