Presence and importance of oxidative stress parameters in malignant mammary gland tumors in dogs
Yazarlar (7)
Doç. Dr. Emin KARAKURT Kafkas Üniversitesi, Türkiye
Prof. Dr. Mushap KURU Kafkas Üniversitesi, Türkiye
Prof. Dr. Serpil DAĞ Kafkas Üniversitesi, Türkiye
Prof. Dr. Enver BEYTUT Kafkas Üniversitesi, Türkiye
Hasan Oral
Kafkas Üniversitesi, Türkiye
Kafkas Üniversitesi, Türkiye
Dr. Öğr. Üyesi Hilmi NUHOĞLU Kafkas Üniversitesi, Türkiye
Dr. Öğr. Üyesi Ayfer YILDIZ UYSAL Kafkas Üniversitesi, Türkiye
| Makale Türü |
Özgün Makale
(SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale)
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| Dergi Adı | Kafkas Universitesi Veteriner Fakultesi Dergisi (Q4) | ||
| Dergi ISSN | 1300-6045 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 08-2021 |
| Cilt / Sayı / Sayfa | 27 / 4 / 517–523 | DOI | 10.9775/kvfd.2021.25919 |
| Makale Linki | http://vetdergikafkas.org/uploads/pdf/pdf_KVFD_2824.pdf | ||
| UAK Araştırma Alanları |
Veteriner Patolojisi
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| Özet |
| This study aimed to evaluate the presence of oxidative stress based on lipid peroxidation and the DNA damage markers malondialdehyde (MDA) and 8-hydroxy-2’-deoxyguanosine (8-OHdG) in canine mammary gland carcinomas using immunohistochemistry techniques. A total of ten malignant and six normal canine mammary tissue samples were evaluated. The specimens were fixed in 10% buffered formaldehyde solution, processed routinely, embedded in paraffin wax, sectioned at 5 μm, stained with hematoxylin and eosin, examined under a light microscope, and photographed to detect histopathological changes. For immunohistochemistry, the avidin-biotin-peroxidase method was performed. All canine mammary gland tumors were immunopositive for MDA and 8-OHdG expression. There was a statistically significant increase in MDA and 8-OHdG expressions in the tumor group compared to the control group. Based on this study data, in the context of oxidative stress, it is proposed that lipid peroxidation and reactive oxygen species (ROS)-induced DNA damage are significantly associated with canine mammary gland tumor development. In addition, antioxidants may be useful in the treatment of canine mammary gland tumors. |
| Anahtar Kelimeler |
| Canine | Carcinoma | Mammary gland | Oxidative stress |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Web of Science | 5 |
| Scopus | 6 |
| Google Scholar | 7 |