Green-synthesized N-acetylcarnosine–loaded gold nanoparticles as a novel ocular nanocarrier for antioxidant therapy and cataract prevention
Yazarlar (3)
Ahmed Salih Abid
Mustansiriyah University, Irak
Mustansiriyah University, Irak
Zahraa S. Al-Garawi
Mustansiriyah University, Irak
Mustansiriyah University, Irak
Doç. Dr. Füreya Elif ÖZTÜRKKAN Kafkas Üniversitesi, Türkiye
| Makale Türü |
Özgün Makale
(SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale)
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| Dergi Adı | Scientific Reports (Q1) | ||
| Dergi ISSN | 2045-2322 Dergi Bilgileri (2026) | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 03-2026 |
| Cilt / Sayı / Sayfa | 16 / 1 / – | DOI | 10.1038/s41598-026-43070-1 |
| Makale Linki | https://doi.org/10.1038/s41598-026-43070-1 | ||
| UAK Araştırma Alanları |
Anorganik Kimya
Spektroskopi
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| Özet |
| Cataract represents one of the leading causes of blindness worldwide and is primarily attributed to protein glycation, oxidative stress, and aggregation of lens crystallins. Surgical lens extraction remains the standard treatment, which, despite its effectiveness, carries potential postoperative risks and economic burdens, thereby underscoring the need for alternative, non-surgical therapeutic approaches. This study aimed to develop a green-synthesized nanosystem based on gold nanoparticles (AuNPs) using Alchemilla vulgaris L. (Lady’s mantle) extract, aiming to achieve efficient antioxidant delivery and sustained therapeutic retention within ocular tissues. Gold nanoparticles were synthesized via the reduction of chloroauric acid (HAuCl·3H2O) using the plant extract under ultrasonic agitation and dispersion, yielding AuNPs formulations 1%, 4%, and 7% (w/v). The synthesized nanocomposites were characterized … |
| Anahtar Kelimeler |
| Alchemilla vulgarisL | Antioxidant nanocarrier | Cataract | Controlled release | Gold nanoparticles (AuNPs) | Green synthesis | In-silico docking | Lens transparency | N-acetylcarnosine (NAC) | Ocular drug delivery |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Web of Science | 1 |
| Scopus | 1 |
| Google Scholar | 2 |