A new series of naphthyl-thiosemicarbazone and thio/carbohydrazone derivatives: Synthesis, spectroscopic elucidation, dual enzyme inhibition targeting carbonic anhydrase …
Yazarlar (5)
Hasan Yakan
Halit Muğlu
Doç. Dr. Musa ERDOĞAN Türkiye
Cüneyt Türkeş
Prof. Dr. Yeliz Demir Kafkas Üniversitesi
| Makale Türü | Özgün Makale (Uluslararası alan indekslerindeki dergilerde yayınlanan tam makale) | ||
| Dergi Adı | Archives of Biochemistry and Biophysics | ||
| Makale Dili | – | Basım Tarihi | 09-2025 |
| Cilt / Sayı / Sayfa | 771 / 0 / 110491–0 | DOI | – |
| Makale Linki | https://www.sciencedirect.com/science/article/pii/S0003986125002048 | ||
| UAK Araştırma Alanları |
Organik Kimya
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| Özet |
| New naphthyl-thiosemicarbazone derivatives (1-9) were obtained from 1-naphthaldehyde and numerous thiosemicarbazides. New naphthyl-thio/carbohydrazones (10-12) were prepared from 1-naphthaldehyde and various thio/carbohydrazides. FT-IR, 1H NMR, 13C NMR, and elemental analysis were used to elucidate the structures of the newly obtained compounds. The inhibitory effects of these compounds against human carbonic anhydrase isoforms I and II (hCA I and hCA II) and acetylcholinesterase (AChE) were systematically evaluated. Several compounds exhibited potent inhibition, particularly derivatives bearing halogenated and electron-donating aromatic substituents. Among them, compound 11 demonstrated the strongest inhibition for all three enzymes, with Ki values of 52.42 nM (hCA I), 59.23 nM (hCA II), and 40.16 nM (AChE), surpassing the reference standards acetazolamide and tacrine. Structure … |
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