The effect of diclofenac sodium intoxication on the cardiovascular system in rats
Yazarlar (4)
Turgut Dolanbay Kafkas Üniversitesi, Türkiye
Doç. Dr. Mustafa MAKAV Kafkas Üniversitesi, Türkiye
Doç. Dr. Hüseyin Fatih GÜL Kafkas Üniversitesi, Türkiye
Doç. Dr. Emin KARAKURT Kafkas Üniversitesi, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | AMERICAN JOURNAL OF EMERGENCY MEDICINE (Q2) | ||
| Dergi ISSN | 0735-6757 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 08-2021 |
| Kabul Tarihi | 12-04-2026 | Yayınlanma Tarihi | – |
| Cilt / Sayı / Sayfa | 46 / 2021 / 560–566 | DOI | 10.1016/j.ajem.2020.11.022 |
| Makale Linki | https://reader.elsevier.com/reader/sd/pii/S0735675720310317?token=A5CA29A49E27B681A93A14B060240E89A1E283FC8F1B6861232DB8F44FD54D43653BD523BEDEC868B609540D713EA812&originRegion=eu-west-1&originCreation=20210922121129 | ||
| Özet |
| ObjectivesDiclofenac sodium (DS) is a widely used nonsteroidal anti-inflammatory drug. Although its high doses are known to cause toxic effects in many tissues including liver and kidney, the effects on the cardiovascular system (CVS) have not been fully elucidated yet. Therefore, this study aimed to investigate the effect of DS on CVS.MethodsThe Control group did not receive medication; however, a single dose of 240 mg/kg DS was administered orally to the DS group. Electrocardiography (ECG) measurements were performed in all animals before (0thhour) and after (1st,6th,12th,24thhour) intoxication. After 24 h, All animals were sacrificed. Biochemical (malondialdehyde [MDA], and glutathione (GSH), Apelin, Elabela, Meteorin, Endoglin, Keap1, and Nrf2) and histopathological analyzes were performed on heart tissue samples.ResultsECG results showed that there was a statistically significant increase in QTc … |
| Anahtar Kelimeler |
| Cardiovascular system | Diclofenac sodium | ECG | Intoxication | Nonsteroidal anti-inflammatory drug |
Science Direct
The effect of diclofenac sodium intoxication on the cardiovascular system in rats
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Google Scholar | 21 |
| Web of Science | 16 |
| Scopus | 16 |