| Yazarlar (2) |
Doç. Dr. Emin KARAKURT
Kafkas Üniversitesi, Türkiye |
Prof. Dr. Serpil DAĞ
Kafkas Üniversitesi, Türkiye |
| Özet |
| The aim of this study was to evaluate the anticancerogenic effect of Silimarin by immunohistochemical methods on Diethylnitrosamine (DEN) induced Hepatocellular carcinoma (HCC) model in Wistar rats. Fifty male Wistar-Albino rats aging 2 months were randomly divided into 5 equal groups. The Control group rats were given pellet feed and drinking water for 20 weeks. The Sham group rats were injected intraperitoneally Propylene glycol dissolved in% 0.9 NaCl three times for 20 weeks. The Silymarin group rats were injected intraperitoneally 100 mg/kg Silymarin three times a week for 20 weeks. The DEN group rats were injected intraperitoneally 50 mg/kg DEN once a week for 20 weeks. The DEN+ Silymarin group rats were injected 50 mg/kg DEN once a week for 20 weeks. Silymarin at a dose of 100 mg/kg was injected intraperitoneally for 21 weeks, three times a week, starting 1 week before DEN administration. At the end of 21 weeks, macroscopically multifocal nodular structures were detected in the DEN and DEN+ Silymarin group. A mix pattern of trabecular and acinar structures of HCC was observed in DEN and DEN+ Silymarin groups. Besides; No statistically significant results were found between DEN and DEN+ Silymarin groups in terms of iNOS, Nitrotyrosine, PCNA, GSTPi, MMP-9, HPIP and TUNEL staining (P> 0.05). In line with the results of our study, we determined that Silymarin did not show the expected anticarcinogenic effect. |
| Anahtar Kelimeler |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | Diğer hakemli uluslarası dergilerde yayınlanan tam makale |
| Dergi Adı | Turkish Veterinary Journal |
| Dergi ISSN | 2667-8292 |
| Dergi Tarandığı Indeksler | ASOS index, Crossref, CiteFactor, ResearchBib, Index Copernicus |
| Makale Dili | İngilizce |
| Basım Tarihi | 07-2020 |
| Cilt No | 2 |
| Sayı | 1 |
| Sayfalar | 7 / 16 |
| Makale Linki | https://dergipark.org.tr/tr/pub/turkvetj/issue/56001/665003 |
