| Yazarlar (2) |
Doç. Dr. Emin KARAKURT
Kafkas Üniversitesi, Türkiye |
Prof. Dr. Serpil DAĞ
Kafkas Üniversitesi, Türkiye |
| Özet |
| Liver cancer is the third most common cancer-related death in the World. Hepatocellular carcinoma (HCC) constitutes %70-85 of liver malignant primary tumors. In this study; we aimed to investigate the role of diethylnitrosamine (DEN) in the experimental liver cancer model and to examine the hepatoprotective effect of silymarin in detail using oxidative-nitrosative stress markers with immunohistochemical methods. For this purpose, 50 Wistar Albino male rats were divided into 5 groups with 10 rats. Animals in DEN group received DEN at a dose of 50 mg/kg once a week for 20 weeks. The rats in the DEN +Silymarin group were Silymarin intraperitoneally for 21 weeks 3 times a week at a dose of 100 mg/kg, starting 1 week prior to the administration of DEN. Silymarin was administered to rats in the group of Silymarin 3 times a week intraperitoneally for 20 weeks at a dose of 100 mg/kg. The rats in the control group were fed pellet feed and drinking water for 20 weeks. Animals in Sham group were treated with propylene glycol dissolved in 0,9 % NaCl intraperitoneally 3 times a week for 20 weeks. At the end of 21 weeks, macroscopically different size and number of nodular structures were detected in the DEN and DEN+Silymarin group. The microscopic examination revealed that the nodules were HCC. As a result, DEN induced liver cancer; however, silymarin did not show a statistically significant protective effect in terms of iNOS and Nitrotyrosine expressions. |
| Anahtar Kelimeler |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | Diğer hakemli uluslarası dergilerde yayınlanan tam makale |
| Dergi Adı | Van Veterinary Journal |
| Dergi ISSN | 2149-3359 |
| Dergi Tarandığı Indeksler | Sobiad, CAB Abstracts, Ebscohost, Index Copernicus, Türkiye Atıf Dizini, Google Scholar, Asos Index |
| Makale Dili | İngilizce |
| Basım Tarihi | 07-2020 |
| Cilt No | 31 |
| Sayı | 2 |
| Sayfalar | 105 / 110 |
| Doi Numarası | 10.36483/vanvetj.680365 |
| Makale Linki | http://www.dergipark.org.tr/tr/pub/vanvetj/issue/55797/680365 |
| Atıf Sayıları | |
| Google Scholar | 4 |
