| Yazarlar |
Doç. Dr. Emin KARAKURT
Kafkas Üniversitesi, Türkiye |
Prof. Dr. Enver BEYTUT
Kafkas Üniversitesi, Türkiye |
Prof. Dr. Serpil DAĞ
Kafkas Üniversitesi, Türkiye |
Dr. Öğr. Üyesi Hilmi NUHOĞLU
Kafkas Üniversitesi, Türkiye |
Arş. Gör. Ayfer YILDIZ UYSAL
Kafkas Üniversitesi, Türkiye |
Emre Kurtbaş
Türkiye |
| Özet |
| This study aimed to examine the tumor necrosis factor alpha and interferon gamma expressions in the tumor microenvironment of ovine pulmonary adenocarcinomas of different growth patterns and stages by immunohistochemistry and to investigate the effects of these cytokines on the tumor progression. The material of the present study consisted of lung tissue samples of 26 sheep. Lung tissues were fixed in 10% neutral buffered formalin, and later, routine procedures tissues were embedded in paraffin wax. To detect histopathological changes, 5-μm tissue sections were cut and stained with hematoxylin and eosin. Avidin-biotin peroxidase method was used for immunohistochemistry . Tumoral cells showed acinar, papillary, or mixed-type growths in ovine pulmonary adenocarcinomas. No expressions of tumor necrosis factor alpha and interferon gamma was observed in the control group, whereas all ovine pulmonary adenocarcinomas were immunohistochemically positive for tumor necrosis factor alpha and interferon gamma. In advanced-stage cases, the reactions were much more severe than in early-stage cases. The reactions were particularly concentrated in the cytoplasm of alveolar macrophages around the tumoral areas. Tumor necrosis factor alpha and interferon gamma can be remarkable markers to evaluate the severity of disease. |
| Anahtar Kelimeler |
| Cytokines | IFN-? | inflammation | ovine pulmonary adenocarcinoma | TNF-a |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | ESCI dergilerinde yayımlanan tam makale |
| Dergi Adı | ACTA VETERINARIA EURASIA |
| Dergi ISSN | 2618-639X |
| Dergi Tarandığı Indeksler | Web of Science-Emerging Sources Citation Index Web of Science- Zoological Records Scopus DOAJ EBSCO TUBITAK ULAKBIM TR Index China National Knowledge Infrastructure (CNKI) Embase Gale AGRIS Nutrition Abstracts and Reviews Series B:Livestock Feeds Nutrition and Food Database Parasitology Database Review of Medical and Veterinary Mycology Veterinary Bulletin CABI AgBiotechNet CABI Animal Breeding Abtracts CABI Animal Science Database CABI CAB Abstracts CABI Dairy Science Abstract CABI Helmintological Abstracts CABI Index Veterinarius CABI VetMed Resource CABI Poultry Abstracts CABI Tropical Diseases Bulletin |
| Makale Dili | İngilizce |
| Basım Tarihi | 09-2022 |
| Cilt No | 48 |
| Sayı | 3 |
| Sayfalar | 161 / 166 |
| Doi Numarası | 10.5152/actavet.2022.21124 |
| Makale Linki | https://actavet.org/en/immunohistochemical-detection-of-tnf-and-ifn-expressions-in-the-lungs-of-sheep-with-pulmonary-adenocarcinomas-16661 |
| Atıf Sayıları | |
| SCOPUS | 1 |
| Google Scholar | 2 |
