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CD3, CD79αcy, vimentin, α-smooth muscle actin, S100 and cytokeratin 5/6 expression in immunohistochemical characterization of dogs with transmissible venereal tumors    
Yazarlar (8)
Doç. Dr. Emin KARAKURT Doç. Dr. Emin KARAKURT
Kafkas Üniversitesi, Türkiye
Prof. Dr. Mushap KURU Prof. Dr. Mushap KURU
Kafkas Üniversitesi, Türkiye
Prof. Dr. Serpil DAĞ Prof. Dr. Serpil DAĞ
Kafkas Üniversitesi, Türkiye
Prof. Dr. Enver BEYTUT Prof. Dr. Enver BEYTUT
Kafkas Üniversitesi, Türkiye
Dr. Öğr. Üyesi Hilmi NUHOĞLU Dr. Öğr. Üyesi Hilmi NUHOĞLU
Kafkas Üniversitesi, Türkiye
Dr. Öğr. Üyesi Murat Can DEMİR Dr. Öğr. Üyesi Murat Can DEMİR
Kafkas Üniversitesi, Türkiye
Arş. Gör. Ayfer YILDIZ UYSAL Arş. Gör. Ayfer YILDIZ UYSAL
Türkiye
Prof. Dr. Cihan KAÇAR Prof. Dr. Cihan KAÇAR
Kafkas Üniversitesi, Türkiye
Devamını Göster
Özet
Transmissible Venereal Tumor (TVT) is a highly contagious round cell tumor and its origin is unknown. In our study, we aimed to evaluate CD3, CD79αcy, vimentin, α-smooth muscle actin, S100, and cytokeratin 5/6 expressions immunohistochemically in order to reveal the cellular characterization of TVT. The material of this study consisted of ten dog tissue sections, six females and four males diagnosed with TVT. Tissue samples from dogs were fixed in a 10% buffered formaldehyde solution. After routine tissue procedures follow-up, Hematoxylin & Eosin stain was applied to the sections and investigated under a light microscope. The smear prepared from the tumor was examined with the Diff-Quick method for cytologically. Immunohistochemical staining was performed on the tissues using the avidin-biotin immune peroxidase complex method. Based on macroscopic, histopathological and cytological findings, we decided that the cases were TVT. All cases were negative for all markers except vimentin expression in round tumoral cells. The negative immunoreactivity of CD3, CD79αcy, α-smooth muscle actin, and cytokeratin 5/6 in tumor cells suggests that the origin of the tumor is not lymphocytic, smooth muscle cells or epithelial. Only the option of histiocytic origin remains.
Anahtar Kelimeler
Makale Türü Özgün Makale
Makale Alt Türü Diğer hakemli uluslarası dergilerde yayınlanan tam makale
Dergi Adı Turkish Veterinary Journal
Dergi ISSN 2667-8292
Dergi Tarandığı Indeksler ASOS index, Crossref, CiteFactor, ResearchBib, Index Copernicus
Makale Dili İngilizce
Basım Tarihi 12-2020
Cilt No 2
Sayı 2
Sayfalar 54 / 61
Makale Linki https://dergipark.org.tr/tr/pub/turkvetj
BM Sürdürülebilir Kalkınma Amaçları
Atıf Sayıları
Google Scholar 3

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