The Role of Reduced Glutathione on the Activity of Adenosine Deaminase, Antioxidative System, and Aluminum and Zinc Levels in Experimental Aluminum Toxicity
Yazarlar (8)
Prof. Dr. Onur ATAKİŞİ
Kafkas Üniversitesi, Türkiye
Dr. Öğr. Üyesi Kezban YILDIZ DALGINLI
Kafkas Üniversitesi, Türkiye
Dr. Öğr. Üyesi Destan KALAÇAY
Kafkas Üniversitesi, Türkiye
Prof. Dr. Emine ATAKİŞİ
Kafkas Üniversitesi, Türkiye
Tünay Kontaş Aşkar
Türkiye
Ruken Esra Demirdöğen
Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | Springer Science and Business Media LLC (Q2) | ||
| Dergi ISSN | 0163-4984 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 01-2023 |
| Cilt / Sayı / Sayfa | 201 / 0 / 4429–4436 | DOI | 10.1007/s12011-022-03503-0 |
| Makale Linki | http://dx.doi.org/10.1007/s12011-022-03503-0 | ||
| Özet |
| Aluminum (Al) is one of the most abundant element in the world. But aluminum exposure and accumulation causes serious diseases, related with free radicals. Reduced glutathione (GSH) is a tripeptide with intracellular antioxidant effects. This study aimed to investigate the role of GSH on adenosine deaminase (ADA), antioxidant system, and aluminum and zinc (Zn) levels in acute aluminum toxicity. In this study, Sprague–Dawley rats (n = 32) were used. The rats were divided into four equal groups (n = 8). Group I received 0.5 mL intraperitoneal injection of 0.9% saline solution (NaCI), Group II received single-dose AlCI3, Group III was given GSH for seven days, and Group IV was given AlCI3 single dose, and at the same time, 100 mg/kg GSH was given for seven days. At the end of the trial, blood samples were collected by cardiac puncture. Serum total antioxidant status (TAS) and Zn levels were lower in the … |
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BM Sürdürülebilir Kalkınma Amaçları
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| Google Scholar | 7 |