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The Role of Reduced Glutathione on the Activity of Adenosine Deaminase, Antioxidative System, and Aluminum and Zinc Levels in Experimental Aluminum Toxicity   
Yazarlar (8)
Prof. Dr. Onur ATAKİŞİ Prof. Dr. Onur ATAKİŞİ
Türkiye
Dr. Öğr. Üyesi Kezban YILDIZ DALGINLI Dr. Öğr. Üyesi Kezban YILDIZ DALGINLI
Türkiye
Canan Gülmez Samsa
Türkiye
Dr. Öğr. Üyesi Destan KALAÇAY Dr. Öğr. Üyesi Destan KALAÇAY
Türkiye
Prof. Dr. Emine ATAKİŞİ Prof. Dr. Emine ATAKİŞİ
Kafkas Üniversitesi, Türkiye
Zhumabaeva Taasilkan Toktamamatovna
Türkiye
Tünay Kontaş Aşkar
Türkiye
Ruken Esra Demirdöğen
Türkiye
Devamını Göster
Özet
Aluminum (Al) is one of the most abundant element in the world. But aluminum exposure and accumulation causes serious diseases, related with free radicals. Reduced glutathione (GSH) is a tripeptide with intracellular antioxidant effects. This study aimed to investigate the role of GSH on adenosine deaminase (ADA), antioxidant system, and aluminum and zinc (Zn) levels in acute aluminum toxicity. In this study, Sprague–Dawley rats (n = 32) were used. The rats were divided into four equal groups (n = 8). Group I received 0.5 mL intraperitoneal injection of 0.9% saline solution (NaCI), Group II received single-dose AlCI3, Group III was given GSH for seven days, and Group IV was given AlCI3 single dose, and at the same time, 100 mg/kg GSH was given for seven days. At the end of the trial, blood samples were collected by cardiac puncture. Serum total antioxidant status (TAS) and Zn levels were lower in the …
Anahtar Kelimeler
Makale Türü Özgün Makale
Makale Alt Türü SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale
Dergi Adı Springer Science and Business Media LLC
Dergi ISSN 0163-4984 Wos Dergi Scopus Dergi
Dergi Tarandığı Indeksler SCI-Expanded
Dergi Grubu Q2
Makale Dili İngilizce
Basım Tarihi 01-2023
Cilt No 201
Sayfalar 4429 / 4436
Doi Numarası 10.1007/s12011-022-03503-0
Makale Linki http://dx.doi.org/10.1007/s12011-022-03503-0