Lactoferrin modulates increased liver DNA damage by reducing serum cytokine, hepcidin and iron levels in lipopolysaccharide-induced endotoxemia in rats
Yazarlar (4)
Dr. Öğr. Üyesi Kezban YILDIZ DALGINLI
Kafkas Üniversitesi, Türkiye
Prof. Dr. Emine ATAKİŞİ
Kafkas Üniversitesi, Türkiye
Prof. Dr. Onur ATAKİŞİ
Kafkas Üniversitesi, Türkiye
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Özgün Makale
(SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale)
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| Dergi Adı | Babes-Bolyai University (Q4) | ||
| Dergi ISSN | 1224-7154 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | Türkçe | Basım Tarihi | 03-2022 |
| Cilt / Sayı / Sayfa | 67 / 1 / 165–175 | DOI | 10.24193/subbchem.2022.1.11 |
| Makale Linki | https://doi.org/10.24193/subbchem.2022.1.11 | ||
| Özet |
| Endotoxemia, known as the presence of Gram (-) bacterial endotoxin in the circulation, is associated with high mortality. Here, it was aimed to investigate the effects of lactoferrin on inflammation and iron homeostasis and cytokine production in lipopolysaccharide (LPS)-induced experimental endotoxemia in rats. Tumor necrosis factor (TNF-[alpha]) and interferon gamma (IFN-y) levels, which are important cytokines, and iron and hepcidin levels, which play a role in iron homeostasis, DNA damage marker 8-hydroxy-2'-deoxyguanosine levels were evaluated in endotoxemia model. Enzyme-linked Immunosorbent Assay (ELISA) method is a technique based on antigen-antibody complex and using enzymes as marking. Serum TNF-[alpha], IFN-y and hepcidin levels and the liver 8-OHdG levels were measured by ELISA methods, serum iron levels were determined using iron assay kit. The results indicated that … |
| Anahtar Kelimeler |
BM Sürdürülebilir Kalkınma Amaçları
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