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Lactoferrin modulates increased liver DNA damage by reducing serum cytokine, hepcidin and iron levels in lipopolysaccharide-induced endotoxemia in rats   
Yazarlar (4)
Canan Gülmez Samsa
Türkiye
Dr. Öğr. Üyesi Kezban YILDIZ DALGINLI Dr. Öğr. Üyesi Kezban YILDIZ DALGINLI
Türkiye
Prof. Dr. Emine ATAKİŞİ Prof. Dr. Emine ATAKİŞİ
Kafkas Üniversitesi, Türkiye
Prof. Dr. Onur ATAKİŞİ Prof. Dr. Onur ATAKİŞİ
Türkiye
Devamını Göster
Özet
Endotoxemia, known as the presence of Gram (-) bacterial endotoxin in the circulation, is associated with high mortality. Here, it was aimed to investigate the effects of lactoferrin on inflammation and iron homeostasis and cytokine production in lipopolysaccharide (LPS)-induced experimental endotoxemia in rats. Tumor necrosis factor (TNF-[alpha]) and interferon gamma (IFN-y) levels, which are important cytokines, and iron and hepcidin levels, which play a role in iron homeostasis, DNA damage marker 8-hydroxy-2'-deoxyguanosine levels were evaluated in endotoxemia model. Enzyme-linked Immunosorbent Assay (ELISA) method is a technique based on antigen-antibody complex and using enzymes as marking. Serum TNF-[alpha], IFN-y and hepcidin levels and the liver 8-OHdG levels were measured by ELISA methods, serum iron levels were determined using iron assay kit. The results indicated that …
Anahtar Kelimeler
Makale Türü Özgün Makale
Makale Alt Türü SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale
Dergi Adı Babes-Bolyai University
Dergi ISSN 1224-7154 Wos Dergi Scopus Dergi
Dergi Tarandığı Indeksler SCI-Expanded
Dergi Grubu Q4
Makale Dili Türkçe
Basım Tarihi 03-2022
Cilt No 67
Sayı 1
Sayfalar 165 / 175
Doi Numarası 10.24193/subbchem.2022.1.11