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The effects of resveratrol on SIRT2, SIRT3 expression levels and oxidative DNA damage in fumonisin-induced hepatotoxicity in BALB/c mice   
Yazarlar (6)
Canan Gülmez Samsa
Türkiye
Rıza Yalçın
Türkiye
Asım Kart
Türkiye
Prof. Dr. Emine ATAKİŞİ Prof. Dr. Emine ATAKİŞİ
Kafkas Üniversitesi, Türkiye
Moldaliev Z. Tumakovich
Türkiye
Prof. Dr. Onur ATAKİŞİ Prof. Dr. Onur ATAKİŞİ
Türkiye
Devamını Göster
Özet
Oxidative stress, which is characterized by disruption of the oxidant/antioxidant balance, causes pathological processes, including toxicities induced by certain mycotoxins. The present study was designed to investigate the effects of resveratrol on sirtuin deacetylases (SIRT2 and SIRT3), nitric oxide (NO), reduced glutathione (GSH) and malondialdehyde (MDA) in fumonisin B1-induced hepatotoxicity. Regarding the experimental design, forty BALB/c mice were divided into four groups corresponding to the control, resveratrol (10 mg/kg, ip), fumonisin B1 (2.25 mg/kg, ip) and resveratrol+ fumonisin B1 (10 mg/kg+ 2.25 mg/kg) groups. At the end of the 14 day-treatment, expression levels of SIRT2 and SIRT3 protein in the serum and liver were revealed by western blotting and antioxidant/oxidant activity analysis. SIRT2 and SIRT3 expression levels in the liver were significantly decreased by fumonisin B1 in comparison to the control. However, resveratrol supplementation coupled with fumonisin B1 increased the expression levels of SIRT2 and SIRT3, in relation to the fumonisin B1 treatments alone, but did not exhibit significant differences from those of the control group. As substantial indicators of stress and damage, the 8-OH-2-deoxyguanosine, NO and MDA levels of the liver tissue were assayed, and were higher in the fumonisin B1-treated groups, in relation to the control. As expected, resveratrol treatment significantly reduced the levels of NO and MDA in comparison to the fumonisin B1 treatments alone. Also, resveratrol attenuated the liver 8-OH-2-deoxyguanosine levels in the resveratrol+ fumonisin B1 group. In conclusion, the findings revealed …
Anahtar Kelimeler
Makale Türü Özgün Makale
Makale Alt Türü SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale
Dergi Adı VETERINARSKI ARHIV
Dergi ISSN 1331-8055 Wos Dergi Scopus Dergi
Dergi Tarandığı Indeksler SCI-Expanded
Dergi Grubu Q4
Makale Dili Türkçe
Basım Tarihi 01-2022
Cilt No 92
Sayı 1
Sayfalar 97 / 108
Doi Numarası 10.24099/vet.arhiv.1420