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Acute tamoxifen treatment increases nitric oxide level but not totalantioxidant capacity and adenosine deaminase activity in the plasma ofrabbits   
Yazarlar (4)
Prof. Dr. Emine ATAKİŞİ Prof. Dr. Emine ATAKİŞİ
Kafkas Üniversitesi, Türkiye
Asım Kart
Mehmet Akif Ersoy Üniversitesi, Türkiye
Prof. Dr. Onur ATAKİŞİ Prof. Dr. Onur ATAKİŞİ
Kafkas Üniversitesi, Türkiye
Birkan Topçu
Kafkas Üniversitesi, Türkiye
Devamını Göster
Özet
Tamoxifen is a synthetic non steroidal anti-estrogen used to treat patients with breast cancer and healthy subjects with high risk of breast cancer. It was aimed to study the short term effects of tamoxifen on the plasma total antioxidant capacity (TAC), nitric oxide (NO) and the adenosine deaminase activity (ADA) in healthy rabbits. Sixteen healthy New Zealand rabbits were allocated to 2 groups including controls and tamoxifen treated animals. Controls received a single application of 0.9% saline via oral route while the treated rabbits received orally tamoxifen (dissolved in 0.9% saline, at a dose of 5 mg/kg). Blood samples were collected at 6 and 24 hours following the treatments. Plasma TAC and ADA were not affected by Tamoxifen treatment. However, NO level in tamoxifen treated group was increased at 24 hours following tamoxifen treatment as compared to controls.
Anahtar Kelimeler
Makale Türü Özgün Makale
Makale Alt Türü SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale
Dergi Adı EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
Dergi Tarandığı Indeksler SCI-Expanded
Makale Dili İngilizce
Basım Tarihi 01-2009
Cilt No 13
Sayı 4
Sayfalar 239 / 243
BM Sürdürülebilir Kalkınma Amaçları
Atıf Sayıları
Google Scholar 11

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