| Yazarlar (7) |
Hasan Özen
Kafkas Üniversitesi, Türkiye |
Prof. Dr. Ufuk KAMBER
Kafkas Üniversitesi, Türkiye |
|
Musa Karaman
Balıkesir Üniversitesi, Türkiye |
Prof. Dr. Süleyman GÜL
Kafkas Üniversitesi, Türkiye |
Prof. Dr. Emine ATAKİŞİ
Kafkas Üniversitesi, Türkiye |
|
Kadir Özcan
Uşak Üniversitesi, Türkiye |
Prof. Dr. Onur ATAKİŞİ
Kafkas Üniversitesi, Türkiye |
| Özet |
| The aim of this study was to investigate the effects of long term Sodium nitrite (NaNO2) consumption. Swiss albino mice were given NaNO2 (0, 10 and 20 mg/kg/day) as mixed in feed for 8 months. At the end of treatments, animals were sacrificed and selected organs were processed for histopathologic, imunohistochemical, biochemical and genotoxic investigations. Mild to moderate degenerative changes were observed in liver, kidney, intestine, lung and spleen of NaNO2-given mice. Inducible nitric oxide synthase and nitrotyrosine activities increased in liver and kidney of NaNO2-given mice. Proliferating cell nuclear antigen activity increased in liver. Apoptotic cell death was observed in livers of the treatment groups. Liver malondialdehyde level was higher in the treatment groups while no change was seen in kidney. Nitric oxide levels in both liver and kidney of the treatment groups were lower than those of the … |
| Anahtar Kelimeler |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale |
| Dergi Adı | Experimental and Toxicologic Pathology |
| Dergi ISSN | 0940-2993 Wos Dergi Scopus Dergi |
| Dergi Tarandığı Indeksler | SCI-Expanded |
| Makale Dili | İngilizce |
| Basım Tarihi | 10-2014 |
| Cilt No | 66 |
| Sayı | 8 |
| Sayfalar | 367 / 375 |
| Doi Numarası | 10.1016/j.etp.2014.05.003 |
| Makale Linki | http://linkinghub.elsevier.com/retrieve/pii/S0940299314000694 |
| Atıf Sayıları | |
| Google Scholar | 68 |
