Effect of L carnitine on oxidative damage to liver kidney and spleeninduced by phenylhydrazine in mice
Yazarlar (5)
A. Ozcan
E. Atakisi
M. Karapehlivan
O. Atakisi
M. Citil
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | JOURNAL OF APPLIED ANIMAL RESEARCH | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 01-2007 |
| Cilt / Sayı / Sayfa | 32 / 1 / 97–100 | DOI | – |
| UAK Araştırma Alanları |
Veteriner Biyokimyası
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| Özet |
| Ozcan, A., Atakisi, E., Karapehlivan, M., Atakisi, O. and Citil, M. 2007. Effect of L-carnitine on oxidative damage to liver, kidney and spleen induced by phenylhydrazine in mice. J. Appl. Anim. Res., 32: 97–100. To investigate the ameliorative effect ofL- carnitine on phenylhydrazine induced oxidative damage to liver, kidney and spleen, twenty-eight Swiss albino mice were divided into four groups and injected 0.9% NaCl (control), 40 mg/kg/day phenylhydrazine, phenylhydrazine+L-carnitine or 1000 mg/kg/day L-carnitine. Malondialdehyde (MDA) level was found to be significantly (P<0.001) lower in phenylhydrazine+L-carnitine group compared to the phenylhydrazine group in all tissues. Reduced kidney glutathione (GSH) level in phenylhydrazine given group was restored to normal by L-carnitine. However, increased uric acid level by phenylhydrazine was not decreased by L-carnitine administration. It appears that … |
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