| Yazarlar (4) |
Atakisi Onur
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Atakisi Emine
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Atabay Tennur
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Uzun Metehan
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| Özet |
| This study was conducted to evaluate the nitric oxide (NO) and malondialdehyde (MDA) levels of the brain, liver and kidney tissues of rabbits after long term administration of L-arginine, a nitric oxide donor, and N nitro-L-arginine methyl ester (L-NAME), a NO inhibitor. Three groups were established: control group received 0.5 ml isotonic NaCI; L-arginine group was given 200 mg/kg L-arginine and L-NAME group received 100 mg/kg L-NAME by intraperitoneal injection daily for 11 days. Rabbits were euthanized at the end of the experiment, and the brain, liver and kidney tissue samples were collected. Tissue NO and MDA levels were colorimetrically determined. Results revealed that there were no significant differences in the NO and MDA levels of the liver and kidney among the groups. L-arginine treated group had higher brain NO and MDA levels when compared with other groups (P< 0.05). It is suggested that long term administration of L-arginine increases brain tissue NO and MDA when compared with liver and kidney values. |
| Anahtar Kelimeler |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale |
| Dergi Adı | KAFKAS UNIVERSITESI VETERINER FAKULTESI DERGISI |
| Dergi Tarandığı Indeksler | SCI-Expanded |
| Makale Dili | İngilizce |
| Basım Tarihi | 01-2009 |
| Cilt No | 15 |
| Sayı | 1 |
| Sayfalar | 71 / 75 |
