Sheep Pox Virus Induces Proliferation of Type II Pneumocytes in the Lungs
Yazarlar (1)
Prof. Dr. Enver BEYTUT Kafkas Üniversitesi, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | Journal of Comparative Pathology (Q1) | ||
| Dergi ISSN | 0021-9975 Dergi Bilgileri (2010) | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 08-2010 |
| Cilt / Sayı / Sayfa | 143 / 2 / 132–141 | DOI | 10.1016/j.jcpa.2010.01.014 |
| Makale Linki | http://linkinghub.elsevier.com/retrieve/pii/S0021997510000228 | ||
| UAK Araştırma Alanları |
Veterinerlik Patolojisi
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| Özet |
| The present study investigated the expression of pulmonary surfactant proteins (surfactant protein [SP]-A, SP-B, proSP-C), thyroid transcription factor-1 (TTF-1), proliferating cell nuclear antigen (PCNA) and the infiltration of CD3+ T and CD79αcy+ B lymphocytes into the lungs of 10 lambs naturally infected with sheep pox virus. Microscopical examination detected marked epithelial hyperplasia, sheep pox cells and neutrophilic infiltration in pock nodules. Immunohistochemistry demonstrated intense expression of SPs in the cytoplasm of the hyperplastic type II pneumocytes in the nodular pock lesions. These cells displayed a gland-like arrangement. The hyperplastic and the normal bronchiolar epithelium did not express SPs. The nuclei of the hyperplastic and normal type II pneumocytes labelled positively for TTF-1. Strong PCNA positivity indicated epithelial cell proliferation in the pock nodules. Moderate to … |
| Anahtar Kelimeler |
| Electron microscopy | Immunohistochemistry | Lung | Sheep pox | Surfactant proteins | Type II pneumocyte |
Science Direct
Sheep Pox Virus Induces Proliferation of Type II Pneumocytes in the Lungs
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Web of Science | 17 |
| Scopus | 19 |
| Google Scholar | 32 |