Yazarlar |
Yeliz Demir
Ardahan Üniversitesi, Türkiye |
Doç. Dr. Feyzi Sinan TOKALI
Kafkas Üniversitesi, Türkiye |
Doç. Dr. Erbay KALAY
Kafkas Üniversitesi, Türkiye |
Cüneyt Türkeş
Erzincan Binali Yıldırım Üniversitesi, Türkiye |
Pelin Tokalı
Türkiye |
Osman Nuri Aslan
Atatürk Üniversitesi, Türkiye |
Kıvılcım Şendil
Kafkas Üniversitesi, Türkiye |
Şükrü Beydemir
Anadolu Üniversitesi, Türkiye |
Özet |
In the polyol pathway, aldose reductase (AR) catalyzes the formation of sorbitol from glucose. In order to detoxify some dangerous aldehydes, AR is essential. However, due to the effects of the active polyol pathway, AR overexpression in the hyperglycemic state leads to microvascular and macrovascular diabetic problems. As a result, AR inhibition has been recognized as a potential treatment for issues linked to diabetes and has been studied by numerous researchers worldwide. In the present study, a series of acyl hydrazones were obtained from the reaction of vanillin derivatized with acyl groups and phenolic Mannich bases with hydrazides containing pharmacological groups such as morpholine, piperazine, and tetrahydroisoquinoline. The resulting 21 novel acyl hydrazone compounds were investigated as an inhibitor of the AR enzyme. All the novel acyl hydrazones derived from vanillin demonstrated activity in nanomolar levels as AR inhibitors with IC and K values in the range of 94.21 ± 2.33 to 430.00 ± 2.33 nM and 49.22 ± 3.64 to 897.20 ± 43.63 nM, respectively. Compounds 11c and 10b against AR enzyme activity were identified as highly potent inhibitors and showed 17.38 and 10.78-fold more effectiveness than standard drug epalrestat. The synthesized molecules' absorption, distribution, metabolism, and excretion (ADME) effects were also assessed. The probable-binding mechanisms of these inhibitors against AR were investigated using molecular-docking simulations. |
Anahtar Kelimeler |
Aldose reductase | Acyl hydrazones | Vanillin | Epalrestat | In silico study | ADME-Tox | Molecular docking |
Makale Türü | Özgün Makale |
Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayımlanan tam makale |
Dergi Adı | MOLECULAR DIVERSITY |
Dergi ISSN | 1381-1991 |
Dergi Tarandığı Indeksler | SCI-Expanded |
Dergi Grubu | Q2 |
Makale Dili | İngilizce |
Basım Tarihi | 08-2023 |
Cilt No | 27 |
Sayı | 4 |
Sayfalar | 1713 / 1733 |
Doi Numarası | 10.1007/s11030-022-10526-1 |
Makale Linki | https://link.springer.com/content/pdf/10.1007/s11030-022-10526-1.pdf |