| Yazarlar |
Mehmet Oguz
Selçuk Üniversitesi, Türkiye |
Doç. Dr. Erbay KALAY
Kafkas Üniversitesi, Türkiye |
|
Süleyman Akocak
Adıyaman Üniversitesi, Türkiye |
|
Alessio Nocentini
Türkiye |
|
Nebih Lolak
Adıyaman Üniversitesi, Türkiye |
|
Mehmet Boğa
Dicle Üniversitesi, Türkiye |
|
Mustafa Yılmaz
Selçuk Üniversitesi, Türkiye |
|
Claudıu T Supuran
Türkiye |
| Özet |
| A series of novel calix[4]azacrown substituted sulphonamide Schiff bases was synthesised by the reaction of calix[4]azacrown aldehydes with different substituted primary and secondary sulphonamides. The obtained novel compounds were investigated as inhibitors of six human (h) isoforms of carbonic anhydrases (CA, EC 4.2.1.1). Their antioxidant profile was assayed by various bioanalytical methods. The calix[4]azacrown substituted sulphonamide Schiff bases were also investigated as inhibitors of acetylcholinesterase (AChE), butyrylcholinesterase (BChE) and tyrosinase enzymes, associated with several diseases such as Alzheimer, Parkinson, and pigmentation disorders. The new sulphonamides showed low to moderate inhibition against hCAs, AChE, BChE, and tyrosinase enzymes. However, some of them possessed relevant antioxidant activity, comparable with standard antioxidants used in the study. |
| Anahtar Kelimeler |
| Calix[4]azacrown | enzyme inhibition | antioxidant | carbonic anhydrase |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayımlanan tam makale |
| Dergi Adı | JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY |
| Dergi ISSN | 1475-6366 |
| Dergi Tarandığı Indeksler | SCI-Expanded |
| Dergi Grubu | Q1 |
| Makale Dili | İngilizce |
| Basım Tarihi | 01-2020 |
| Cilt No | 35 |
| Sayı | 1 |
| Sayfalar | 1215 / 1223 |
| Doi Numarası | 10.1080/14756366.2020.1765166 |
| Makale Linki | https://www.tandfonline.com/doi/pdf/10.1080/14756366.2020.1765166?needAccess=true |
| Atıf Sayıları | |
| WoS | 23 |
