| Yazarlar (7) |
Doç. Dr. Erdem TOKTAY
Kafkas Üniversitesi, Türkiye |
Tuğba Bal Taştan
Erzincan Binali Yıldırım Üniversitesi, Türkiye |
|
Muhammet Ali Gürbüz
Atatürk Üniversitesi, Türkiye |
|
Elif Erbaş
Atatürk Üniversitesi, Türkiye |
|
Özlem Özgül Demir
Türkiye |
|
Rüstem Anıl Uğan
Atatürk Üniversitesi, Türkiye |
|
Jale Selli
Alanya Alaaddin Keykubat Üniversitesi, Türkiye |
| Özet |
| We thought that astaxanthin (ASX) might be a protective agent in oxidative stress damage that develops against ischemia and reperfusion injury in the rat ovary. The experimental groups consisted of healthy, I (Ischemia), I+ASX50, I+ASX100, I/R (Ischemia/Reperfusion), I/R+ ASX50, and I/R+ ASX100. Vascular clamps were applied to the ovaries for 3 hr to induce ischemia. For the reperfusion groups, the clamps were opened and blood flow was restored to the ovaries for 3 hr. At the end of the experiment, biochemical, histopathological, and immunohistochemical analyses were made from the tissue samples taken. While MDA levels increased significantly in I and I/R groups, SOD levels decreased. It was found that ASX significantly decreased MDA levels and increased SOD activity in treatment groups depending on the dose. Caspase 3, IL-1 β, and IL-6 expressions were severely increased in ischemia and I/R groups, while the severity of I+ASX50 and I/R+ASX100 immunoreactivity was decreased. While severe hemorrhage areas were observed in I and IR groups, minimal hemorrhage areas were observed in the treatment groups, especially in I/R+ASX100 groups. In addition, inflammatory cells and necrotic cells in the I/R group were not observed in I/R+ASX50 and I/R+ASX100 groups. As a result, it was determined that ASX has a strong protective role against oxidative damage in the treatment of ovarian ischemia-reperfusion injury. |
| Anahtar Kelimeler |
| Astaxanthin | Ischemia | Ovary | Oxidative stress | Rat | Reperfusion |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayımlanan tam makale |
| Dergi Adı | Iranian journal of basic medical sciences |
| Dergi ISSN | 2008-3866 |
| Dergi Tarandığı Indeksler | SCI-Expanded |
| Dergi Grubu | Q3 |
| Makale Dili | Türkçe |
| Basım Tarihi | 02-2022 |
| Cilt No | 25 |
| Sayı | 2 |
| Sayfalar | 173 / 178 |
| Doi Numarası | 10.22038/IJBMS.2022.61289.13559 |
| Makale Linki | https://ijbms.mums.ac.ir/article_19630.html |
| Atıf Sayıları |
