| Yazarlar (7) |
Yasin Bayır
Atatürk Üniversitesi, Türkiye |
|
Abdulmecit Albayrak
Atatürk Üniversitesi, Türkiye |
Doç. Dr. Erdem TOKTAY
Kafkas Üniversitesi, Türkiye |
|
Ufuk Özgen
Karadeniz Teknik Üniversitesi, Türkiye |
|
Cavit Kazaz
Atatürk Üniversitesi, Türkiye |
|
Ayşenur Kahramanlar
|
|
Elif Çadırcı
Atatürk Üniversitesi, Türkiye |
| Özet |
| The genus, which belongs to the Rosaceae family, is known as Lady's mantle and is commonly used in traditional medicine. This study was designed to investigate the major metabolites isolation and gastroprotective effects of . Phytochemical studies were carried out using column chromatography on . The gastroprotective effect of ethanol extract of this plant was tested on indomethacin-induced gastric ulcer model in rats. In addition, superoxide dismutase (SOD), malondialdehyde (MDA), and glutathione (GSH) parameters in the stomach tissue were examined. Quercetin-3-O-glucuronide, apigenin, and catechin were isolated from aerial parts of . When macroscopic ulcer index and histopathological results were analyzed, the extract at 200 mg/kg dose was found to be most effective. All doses of extract reduced MDA level and enhanced SOD activity and GSH level. The results of this study showed that has significant antiulcer activity. This effect was thought to be caused by antioxidant properties of flavonoids. |
| Anahtar Kelimeler |
| Antioxidants | medicinal plants | phythochemicals | ulcer |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | Ulusal alan endekslerinde (TR Dizin, ULAKBİM) yayımlanan tam makale |
| Dergi Adı | The Eurasian Journal of Medicine |
| Dergi ISSN | 1308-8742 |
| Dergi Tarandığı Indeksler | TR DİZİN |
| Makale Dili | İngilizce |
| Basım Tarihi | 10-2020 |
| Cilt No | 52 |
| Sayı | 3 |
| Sayfalar | 249 / 253 |
| Doi Numarası | 10.5152/eurasianjmed.2020.19243 |
| Makale Linki | https://www.eajm.org/en/isolation-of-major-compounds-and-gastroprotective-activity-of-alchemilla-caucasica-on-indomethacin-induced-gastric-ulcers-in-rats-133302 |
| Atıf Sayıları |
