Effect of Prostaglandin E1 Analog Misoprostol in An Ovalbumin-Induced Allergic Rhinitis Model
Yazarlar (9)
Zülküf Kaya Atatürk Üniversitesi, Türkiye
Muhammed Yayla Kafkas Üniversitesi, Türkiye
Nihal Efe Atilla
T.C. Sağlık Bakanlığı, Türkiye
T.C. Sağlık Bakanlığı, Türkiye
Sevilay Özmen Atatürk Üniversitesi, Türkiye
İrfan Çınar Kafkas Üniversitesi, Türkiye
Zafer Bayraktutan Atatürk Üniversitesi, Türkiye
Vahit Mutlu Atatürk Üniversitesi, Türkiye
Harun Ün
Ağrı İbrahim Çeçen Üniversitesi, Türkiye
Ağrı İbrahim Çeçen Üniversitesi, Türkiye
Doç. Dr. Erdem TOKTAY Kafkas Üniversitesi, Türkiye
| Makale Türü |
Özgün Makale
(ESCI dergilerinde yayınlanan tam makale)
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| Dergi Adı | Eurasian Journal of Medicine | ||
| Dergi ISSN | 1308-8734 | ||
| Dergi Tarandığı Indeksler | TR DİZİN | ||
| Makale Dili | İngilizce | Basım Tarihi | 03-2019 |
| Cilt / Sayı / Sayfa | 51 / 1 / 75–79 | DOI | 10.5152/eurasianjmed.2019.19025 |
| Makale Linki | https://www.eajm.org/en/effect-of-prostaglandin-e1-analog-misoprostol-in-an-ovalbumin-induced-allergic-rhinitis-model-1618529 | ||
| Özet |
| Objective: The aim of the present study was to demonstrate the effects of misoprostol in ovalbumin-induced allergic rhinitis (AR). The second purpose was to compare the effect profile of the combination of an antihistamine with misoprostol during treatment of AR.Materials and Methods: Twenty-five adult male rats were used and were randomly classified into five groups (n=5): healthy+saline, AR, AR and desloratadine (D)-treated group, AR and misoprostol (M)-treated group, and AR and combined-treated group.Results: Desloratadine administration had significantly lower nasal symptoms than the AR group, but nasal symptoms in the AR+M group were better than those in the AR+D group. The best improvement in serum IgE levels was seen in the misoprostol alone and combination treatment groups.Conclusion: We suggest that prostaglandins should be considered in the treatment of AR, and that the effects of these types of drugs should be tested clinically in patients. |
| Anahtar Kelimeler |
BM Sürdürülebilir Kalkınma Amaçları
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