| Yazarlar |
Zülküf Kaya
Atatürk Üniversitesi, Türkiye |
Doç. Dr. Muhammed YAYLA
Kafkas Üniversitesi, Türkiye |
|
Nihal Efe Atilla
Türkiye |
|
Sevilay Özmen
Atatürk Üniversitesi, Türkiye |
|
İrfan Çınar
Kafkas Üniversitesi, Türkiye |
|
Zafer Bayraktutan
Atatürk Üniversitesi, Türkiye |
|
Vahit Mutlu
Atatürk Üniversitesi, Türkiye |
|
Harun Ün
Ağrı İbrahim Çeçen Üniversitesi, Türkiye |
Doç. Dr. Erdem TOKTAY
Kafkas Üniversitesi, Türkiye |
| Özet |
| Objective: The aim of the present study was to demonstrate the effects of misoprostol in ovalbumin-induced allergic rhinitis (AR). The second purpose was to compare the effect profile of the combination of an antihistamine with misoprostol during treatment of AR.Materials and Methods: Twenty-five adult male rats were used and were randomly classified into five groups (n=5): healthy+saline, AR, AR and desloratadine (D)-treated group, AR and misoprostol (M)-treated group, and AR and combined-treated group.Results: Desloratadine administration had significantly lower nasal symptoms than the AR group, but nasal symptoms in the AR+M group were better than those in the AR+D group. The best improvement in serum IgE levels was seen in the misoprostol alone and combination treatment groups.Conclusion: We suggest that prostaglandins should be considered in the treatment of AR, and that the effects of these types of drugs should be tested clinically in patients. |
| Anahtar Kelimeler |
| Allergy,desloratadine,misoprostol,rat,rhinitis |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | ESCI dergilerinde yayımlanan tam makale |
| Dergi Adı | The Eurasian Journal of Medicine |
| Dergi ISSN | 1308-8734 |
| Dergi Tarandığı Indeksler | TR DİZİN |
| Makale Dili | İngilizce |
| Basım Tarihi | 03-2019 |
| Cilt No | 51 |
| Sayı | 1 |
| Sayfalar | 75 / 79 |
| Doi Numarası | 10.5152/eurasianjmed.2019.19025 |
| Makale Linki | https://www.eajm.org//en/effect-of-prostaglandin-e1-analog-misoprostol-in-an-ovalbumin-induced-allergic-rhinitis-model-133151 |
| Atıf Sayıları |
