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Is Ebselen A Therapeutic Target in Fracture Healing?     
Yazarlar
Ahmet Kose
Türkiye
Duygu Kose
Türkiye
Zekai Halıcı
Atatürk Üniversitesi, Türkiye
Ali Aydın
Atatürk Üniversitesi, Türkiye
Naci Ezirmik
Atatürk Üniversitesi, Türkiye
Orhan Karsan
Atatürk Üniversitesi, Türkiye
Doç. Dr. Erdem TOKTAY Doç. Dr. Erdem TOKTAY
Kafkas Üniversitesi, Türkiye
Özet
Objective: We investigated the effect of ebselen on fracture healing in an experimental fracture model.Materials and Methods: We divided rats into two groups, 6 rats in each: the experimental femur fracture control group and the ebselen treatment group with an experimental femur fracture. In the experimental femur fracture control group, we created only experimental femur fracture. In the ebselen treatment group, we administered ebselen treatment with creating an experimental femur fracture. We administered ebselen intraperitoneally at 5 mg/kg once daily for 1 month after the 1st day of experimental femur fracture in the ebselen treatment group. We evaluated the recovery status of fractured femurs at the end of 1st month with radiographic, histopathological, and immunohistochemical methods.Results: According to the radiographic fracture healing scores, ebselen treatment increased the extent of new bone formation and fracture cartilage callus significantly compared to the control group. According to the histopathological recovery scores, ebselen treatment significantly improved healing scores compared to the control group. Ebselen treatment increased the expression scores of bone healing markers in the ebselen treatment group, such as vascular endothelial growth factor and osteocalcin, compared to the control group.Conclusion: We demonstrated that ebselen treatment increases the formation of new bone in the femur in an experimentally created femoral fracture model. Ebselen has been shown to improve the bone fracture healing in a radiological and histopathological manner, and more detailed studies are needed.
Anahtar Kelimeler
Makale Türü Özgün Makale
Makale Alt Türü Ulusal alan endekslerinde (TR Dizin, ULAKBİM) yayımlanan tam makale
Dergi Adı The Eurasian Journal of Medicine
Dergi ISSN 1308-8734
Dergi Tarandığı Indeksler TR DİZİN
Makale Dili İngilizce
Basım Tarihi 06-2020
Cilt No 52
Sayı 2
Sayfalar 171 / 175
Makale Linki https://www.eajm.org/en/is-ebselen-a-therapeutic-target-in-fracture-healing-133278
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