| Yazarlar (9) |
Elif Çadırcı
Atatürk Üniversitesi, Türkiye |
|
Zekai Halıcı
Atatürk Üniversitesi, Türkiye |
|
Muhammed Yayla
Kafkas Üniversitesi, Türkiye |
Doç. Dr. Erdem TOKTAY
Kafkas Üniversitesi, Türkiye |
|
Yasin Bayır
Atatürk Üniversitesi, Türkiye |
|
Emre Karakuş
Atatürk Üniversitesi, Türkiye |
|
Atilla Topçu
Recep Tayyip Erdoğan Üniversitesi, Türkiye |
|
Başak Büyük
Çanakkale Onsekiz Mart Üniversitesi, Türkiye |
|
Abdulmecit Albayrak
Atatürk Üniversitesi, Türkiye |
| Özet |
| This study investigated possible role of U-II and its receptor expression in inflammation by using UTR agonist and antagonist in carrageenan induced acute inflammation. Rats were divided into 5 groups as (1) Healthy control, (2) Carrageenan control, (3) Carrageenan +Indomethacin 20mg/kg, orally, (4) Carrageenan +AC7954 (U-II receptor agonist, intraperitoneally) 30mg/kg and (5) Carrageenan +SB657510 (UTR antagonist, intraperitoneally) 30mg/kg. 1h after drug administration, carrageenan was injected. At the 3rd hour after carrageenan injection, agonist produced no effect while antagonist 63% anti-inflammatory effect respectively. UTR and UT-II expression increased in carrageenan induced paw tissue. Antagonist administration prevented the decrease in an antioxidant system and also capable to decrease TNF-α and IL-6 mRNA expressions. This study showed the role of urotensin II receptors in the physiopathogenesis of acute inflammatory response that underlying many diseases accompanied by inflammation. |
| Anahtar Kelimeler |
| Inflammation | Rats | SB657510 | TNF-Alpha | Urotensin II |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale |
| Dergi Adı | Peptides |
| Dergi ISSN | 0196-9781 Wos Dergi Scopus Dergi |
| Dergi Tarandığı Indeksler | SCI |
| Makale Dili | İngilizce |
| Basım Tarihi | 08-2016 |
| Cilt No | 82 |
| Sayfalar | 35 / 43 |
| Doi Numarası | 10.1016/j.peptides.2016.05.006 |
| Makale Linki | http://linkinghub.elsevier.com/retrieve/pii/S0196978116300894 |
| Atıf Sayıları |
