| Yazarlar (5) |
Muhammed Yayla
Kafkas Üniversitesi, Türkiye |
Doç. Dr. Damla BİNNETOĞLU
Kafkas Üniversitesi, Türkiye |
|
Yasemen Adalı
Çanakkale Onsekiz Mart Üniversitesi, Türkiye |
Doç. Dr. Pınar AKSU KILIÇLE
Kafkas Üniversitesi, Türkiye |
Doç. Dr. Erdem TOKTAY
Kafkas Üniversitesi, Türkiye |
| Özet |
| The aim of this study is to determine the therapeutic effects of pomegranate seed oil, which is a powerful antioxidant and anti-inflammatory agent, on ovarian-ischemia and reperfusion injury in rats. Fifty-six female albino Wistar rats were divided into 7 equal groups. Group 1; Sham Operation, Group 2; Ischemia, Group 3; Ischemia + Reperfusion, Group 4; Ischemia + Pomegranate 0,32 ml / kg (IP), Group 5; Ischemia + Pomegranate 0.64 ml / kg, Group 6; Ischemia + Pomegranate 0,32 ml / kg + reperfusion, Group 7; Ischemia + Pomegranate 0,64 ml / kg + reperfusion. Three hours after ischemia and 3 hours after reperfusion, the study was terminated. While NADPH oxidase activity, MDA and TNF-α levels were significantly increased, SOD activity and GSH levels were reduced in ischemia and I/R groups. Low dose pomegranate seed oil application reduced significantly oxidative stress and NADPH oxidase activity in both ischemic and ischemic/reperfusion groups. At the same time, low-dose pomegranate seed oil extract reduced TNF-α levels and significantly increased antioxidant activity. PSO demonstrated an important therapeutic effect in the treatment of ovarian ischemia and reperfusion injury. |
| Anahtar Kelimeler |
| Ischemia/Reperfusion | Ovary | Oxidative stress | Pomegranate seed oil | Punicaceae | Rats |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayımlanan tam makale |
| Dergi Adı | Iranian Journal of Basic Medical Sciences |
| Dergi ISSN | 2008-3866 Wos Dergi Scopus Dergi |
| Dergi Tarandığı Indeksler | SCI-Expanded |
| Makale Dili | İngilizce |
| Basım Tarihi | 12-2018 |
| Cilt No | 12 |
| Sayı | 12 |
| Sayfalar | 1262 / 1268 |
| Doi Numarası | 10.22038/IJBMS.2018.30149.7268 |
| Atıf Sayıları |
