Determination of Cardiac Troponin I in the Blood and Heart of Calves with Foot and Mouth Disease
Yazarlar (5)
Hidayet Metin Erdoğan Kafkas Üniversitesi, Türkiye
Ahmet Ünver Çanakkale Onsekiz Mart Üniversitesi, Türkiye
Prof. Dr. Ali Haydar KIRMIZIGÜL Kafkas Üniversitesi, Türkiye
Prof. Dr. Onur ATAKİŞİ Kafkas Üniversitesi, Türkiye
Prof. Dr. Erhan GÖKÇE Kafkas Üniversitesi, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | Journal of Veterinary Diagnostic Investigation (Q4) | ||
| Dergi ISSN | 1040-6387 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 09-2008 |
| Cilt / Sayı / Sayfa | 20 / 5 / 598–605 | DOI | 10.1177/104063870802000510 |
| Makale Linki | http://vdi.sagepub.com/lookup/doi/10.1177/104063870802000510 | ||
| Özet |
| The current study was designed to determine the changes of the cardiac troponin I (cTnI) expression in blood and tissue during the myocardial degeneration in calves with foot-and-mouth disease (FMD). Seventeen crossbred calves presenting pathological signs for FMD confirmed by viral analysis were studied. A biochemistry panel and immunohistochemistry were performed on 17 diseased calves and 7 calves used as controls. Creatine kinase (CK), CK-myocardial band (CK-MB), aspartate aminotransferase (AST), and lactate dehydrogenase (LDH) activities were analyzed for both groups. Cardiac troponin I levels were measured by a commercially available enzyme-linked immunosorbent assay kit. Mean cTnI (14.8 ± 1.9 ng/ml) concentration and CK (573 ± 407 U/l), CK-MB (238 ± 37 U/l), AST (84 ± 7), and LDH (298 ± 29 U/l) activities were higher in FMD cases compared with controls. Immunohistochemistry revealed loss or depletion of cTnI expression in myocardium of all cases. None of the 7 controls showed loss of cTnI expression. Increased serum cTnI concentration correlated with myocardial injury and loss of cTnI immunolabeling in cardiomyocytes of calves with FMD. |
| Anahtar Kelimeler |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları |