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The Effect of Oral Ampicilin Applications on Liver Mineral Status       
Yazarlar (7)
Başaran Karademir
Kafkas Üniversitesi, Türkiye
Güler Karademir
Türkiye
Serdal Tarhane
Türkiye
Ünal Çiftçi
Türkiye
Doç. Dr. Evren KOÇ Doç. Dr. Evren KOÇ
Kafkas Üniversitesi, Türkiye
Yusuf Ersan
Türkiye
Prof. Dr. Kadir BOZUKLUHAN Prof. Dr. Kadir BOZUKLUHAN
Kafkas Üniversitesi, Türkiye
Devamını Göster
Özet
This study was carried out to determine the changes of Cu, Zn, Fe, Ca, Mg, K and Na levels in liver during treatment of oral ampicillin in mice. The investigation was supported by serum ALT and AST enzyme activities, serum Total Protein (TP), Albumin (ALB), Globulin (GLB) levels determinations. Twenty one male Swiss albino mice (weighing 28.36±2.33 g, aged 4 months) were used for this study. The standard commercial diet was given to all groups. First group (A) were used control and took only tap water. Other groups were received water with ampicillin. Dose of ampicillin for second (B) and third (C) groups were as follows; 8 and 40 mg/100 mL in drinking water. Dry ashing method and Flame Atomic Absorphon Spectrometer (FAAS) were used for determination of minerals. Statistically significant increase (minimum p<0.05) for Cu, Ca and Na and decrease for K were observed. Significant positive correlation between Cu-Ca, Cu-Na, Zn-Mg, Ca-Na, Mg-K (minimum r = 0.450, p<0.05) and negative correlation between Cu-K (r = 0.456, p<0.05) were observed. There was a significant difference in AST levels of groups (p<0.001) but not other serum parameters of ALT, TP, ALB and GLB. These results indicate that oral ampicillin treatment affect liver Cu, Ca, Na andK levels. Therefore, this fluctuation must be considered on ampicillin applications during antimicrobial therapy. © Medwell Journals, 2009.
Anahtar Kelimeler
Ampicillin | liver | Cu, Zn, Fe, Ca, Mg, K, Na, level
Makale Türü Özgün Makale
Makale Alt Türü SSCI, AHCI, SCI, SCI-Exp dergilerinde yayımlanan tam makale
Dergi Adı JOURNAL OF ANIMAL AND VETERINARY ADVANCES
Dergi ISSN 1680-5593
Dergi Tarandığı Indeksler SCI-Expanded
Makale Dili İngilizce
Basım Tarihi 09-2009
Cilt No 8
Sayı 9
Sayfalar 1846 / 1850
BM Sürdürülebilir Kalkınma Amaçları
Atıf Sayıları
WoS 3
SCOPUS 3
Google Scholar 13

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