Development of new thiosemicarbazones with strong α-glucosidase and antioxidant action
Yazarlar (10)
Memona Kamal
Bahauddin Zakariya University, Pakistan
Bahauddin Zakariya University, Pakistan
Dr. Öğr. Üyesi Nastaran Sadeghıan Bartın Üniversitesi, Türkiye
Doç. Dr. Feyzi Sinan TOKALI Kafkas Üniversitesi, Türkiye
Mostafa A. Ismaıl
King Khalid University, Suudi Arabistan
King Khalid University, Suudi Arabistan
Doç. Dr. Parham Taslımı Bartın Üniversitesi, Türkiye
Rıma D. Alharthy
King Abdulaziz University, Suudi Arabistan
King Abdulaziz University, Suudi Arabistan
Asıf Rasool Nanjing University, Çin
Doç. Dr. Orhan ULUÇAY Kafkas Üniversitesi, Türkiye
Doç. Dr. Halil Şenol Bezm-İ Âlem Vakıf Üniversitesi, Türkiye
Zahıd Shafıq
Bahauddin Zakariya University, Pakistan
Bahauddin Zakariya University, Pakistan
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | Future Medicinal Chemistry (Q3) | ||
| Dergi ISSN | 1756-8919 Dergi Bilgileri (2026) | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 06-2026 |
| Cilt / Sayı / Sayfa | 18 / 12 / 1481–1494 | DOI | 10.1080/17568919.2026.2675874 |
| Makale Linki | https://doi.org/10.1080/17568919.2026.2675874 | ||
| UAK Araştırma Alanları |
Organik Kimya
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| Özet |
| AimThis study aimed to synthesize a new series of thiosemicarbazone derivatives (4a-r) as multifunctional antidiabetic candidates with dual α-glucosidase (α-Glu) inhibitory and antioxidant activities to address both hyperglycemia and oxidative stress in diabetes management.Materials and methodsCompounds were synthesized and characterized spectroscopically. The in vitro studies were done on compounds for α-Glu inhibitory and metal-chelating properties. The docking studies and MM-GBSA experimental analyses were implemented for the evaluation of binding strength, coupled with 500 ns molecular dynamics in order to validate the stability of the enzyme-ligand complex. ADME prediction tools were employed to evaluate pharmacokinetic suitability.ResultsCompound 4d (p-methylbenzyl) showing the strongest α-Glu inhibition (IC50 = 206.91 nM, Ki = 235.86 nM), significantly surpassing acarbose … |
| Anahtar Kelimeler |
| antioxidant | Aryl sulfonate | diabetes mellitus | molecular dynamics | thiosemicarbazone |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Google Scholar | 1 |