The Therapeutic Role of Glutathione in Oxidative Stress and Oxidative DNA Damage Caused by Hexavalent Chromium
Yazarlar (6)
Asım Kart Burdur Mehmet Akif Ersoy Üniversitesi, Türkiye
Prof. Dr. Evren KOÇ Kafkas Üniversitesi, Türkiye
Kezban Yıldız Dalgınlı Kafkas Üniversitesi, Türkiye
Canan Gülmez Kafkas Üniversitesi, Türkiye
Doç. Dr. Mustafa SERTÇELİK Kafkas Üniversitesi, Türkiye
Prof. Dr. Onur ATAKİŞİ Kafkas Üniversitesi, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | Biological Trace Element Research | ||
| Dergi ISSN | 0163-4984 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI | ||
| Makale Dili | İngilizce | Basım Tarihi | 12-2016 |
| Cilt / Sayı / Sayfa | 174 / 2 / 387–391 | DOI | 10.1007/s12011-016-0733-0 |
| Makale Linki | http://link.springer.com/10.1007/s12011-016-0733-0 | ||
| Özet |
| Hexavalent chromium Cr (VI) causes various toxic and carcinogenic effects. The main carcinogenic effect is observed in the pulmonary system through inhalation route. Reduction of Cr (VI) to Cr (V, IV, and III) reactive intermediates within the cells by intracellular reducing agents such as glutathione is an important event leading to oxidative stress and oxidative DNA damage. This study evaluated the effects of intraperitoneal administration of Cr (VI) and GSH on total oxidant status (TOS), total antioxidant capacity (TAC), oxidative stress index, and oxidative DNA damage by evaluating the level of 8-hydroxy-2́-deoxyguanosine (8-OHdG) in Swiss-Albino mice. Seventy two mice were divided into 6 groups and treated intraperitoneally as follow: control (saline), group GSH (30 mg/kg GSH) groups of Cr-20 (20 mg/kg, K2Cr2O7), Cr-30 (30 mg/kg K2Cr2O7), Cr-20 + GSH (20 mg/kg K2Cr2O7 + 30 mg/kg GSH), Cr-30 + GSH … |
| Anahtar Kelimeler |
| Hexavalent chromium | GSH | Oxidative stress | DNA damage |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Google Scholar | 58 |
| Web of Science | 36 |