The effect of caffeic acid phenethyl ester (CAPE) on hepatic histopathology and oxidative stress in rats treated with malathion
Yazarlar (7)
Gökhan Nur Gaziantep Üniversitesi, Türkiye
Mehmet Tahir Hüsunet Çukurova Üniversitesi, Türkiye
İzzettin Güler Gaziantep Üniversitesi, Türkiye
Ayla Deveci Gaziantep Üniversitesi
Prof. Dr. Evren KOÇ Kafkas Üniversitesi, Türkiye
Nur Özlem
Doç. Dr. Pınar AKSU KILIÇLE Kafkas Üniversitesi, Türkiye
| Makale Türü |
Özgün Makale
(Ulusal alan endekslerinde (TR Dizin, ULAKBİM) yayınlanan tam makale)
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| Dergi Adı | Medicine Science International Medical Journal | ||
| Dergi ISSN | 2147-0634 | ||
| Dergi Tarandığı Indeksler | TR DİZİN | ||
| Makale Dili | Türkçe | Basım Tarihi | 09-2018 |
| Cilt / Sayı / Sayfa | 7 / 3 / 604–609 | DOI | 10.5455/medscience.2018.07.8833 |
| Makale Linki | https://www.ejmanager.com/fulltextpdf.php?mno=293263 | ||
| Özet |
| Malathion is a broad-spectrum organophosphate insecticide used in the agricultural industry. Our study aimed to investigate the protective effects of caffeic acid phenethyl ester (CAPE) against malathion by examining histopathological and biochemical parameters. Forty Sprague-Dawley male rats were used in this study. Groups formed; group I (control), only 5 ml kg-1 oral corn oil; group II (malathion), 40 mg kg-1 malathion by gavage; group III (malathion+ CAPE), intraperitoneal (ip) CAPE (10 μmol kg-1) followed by intragastric malathion (40 mg kg-1) after 1 hour; group IV (CAPE), intraperitoneal CAPE (10 μmol kg-1). At the end of the administrations, rats were anesthetised with ketamine/xylazine intraperitoneally and euthanasia was performed with cervical dislocation. Their intracardiac blood was drawn under anaesthesia, and after the euthanasia, their liver tissues were removed for histopathological analysis. In group II that was treated with malathion, cell infiltrations around the central and portal vein, degeneration and focal necrosis areas in the liver were detected. Although the histopathological findings observed in the malathion group were also encountered in group III (malathion+ CAPE), lesions were less severe. In the malathion group II, total oxidant status (TOS) and total sialic acid (TSA) levels in plasma increased compared with the control group, while total antioxidant status (TAS) decreased compared with the control group. In the Malathion+ CAPE group III, it was observed that biochemical parameters were closer to the control group. In malathion-treated rats, it was determined that CAPE reduced the degeneration in the liver and it … |
| Anahtar Kelimeler |
BM Sürdürülebilir Kalkınma Amaçları
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| Google Scholar | 11 |