Gastroprotective and Antioxidant Effects of Lobaria pulmonaria and Its Metabolite Rhizonyl Alcohol on Indomethacin Induced Gastric Ulcer
Yazarlar (8)
Dr. Öğr. Üyesi Fadime DUMLU
Kafkas Üniversitesi, Türkiye
Prof. Dr. Fehmi ODABAŞOĞLU
Kafkas Üniversitesi, Türkiye
Mesut Bünyami Halıcı
Atatürk Üniversitesi, Türkiye
Ahmet Çakır
Kilis 7 Aralık Üniversitesi, Türkiye
Elif Çadırcı
Atatürk Üniversitesi, Türkiye
Ali Aslan
Atatürk Üniversitesi, Türkiye
Özlem Aydın Berktaş
Atatürk Üniversitesi, Türkiye
Cavit Kazaz
Atatürk Üniversitesi, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | Chemistry Biodiversity | ||
| Dergi ISSN | 1612-1872 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI | ||
| Makale Dili | İngilizce | Basım Tarihi | 11-2015 |
| Cilt / Sayı / Sayfa | 12 / 11 / 1756–1767 | DOI | 10.1002/cbdv.201400432 |
| Makale Linki | http://doi.wiley.com/10.1002/cbdv.201400432 | ||
| Özet |
| AbstractTwo lichen metabolites, rhizonaldehyde (1) and rhizonyl alcohol (2), were isolated from the acetone extract of Lobaria pulmonaria by chromatographic methods, and their chemical structures were determined by UV/VIS, IR, and 1D‐ and 2D‐NMR spectroscopic methods. The gastroprotective and in vivo antioxidant activities of extracts of L. pulmonaria and its metabolites, 1 and 2, were investigated in indomethacin‐induced ulcer models in rats. The gastric lesions were significantly reduced by acetone, hexane, and CHCl3 extracts, with 75.3–41.5% inhibition. Rhizonyl alcohol (2) significantly reduced the gastric lesions with an inhibition rate of 84.6–42.8%, whereas rhizonaldehyde (1) significantly increased the gastric lesions. Antioxidant parameters and myeloperoxidase activities were also evaluated in the gastric tissues of the rats. Indomethacin caused oxidative stress, which resulted in lipid peroxidation in gastric tissues by decreasing the levels of the antioxidants as compared to healthy rat tissues. In contrast to indomethacin, all extracts and rhizonyl alcohol (2) caused a significant decrease in lipid peroxidation levels and an increase in antioxidant parameters, superoxide dismutase, glutathione peroxidase, and glutathione‐S‐transferase, and reduced glutathione in gastric tissues. The administration of rhizonyl alcohol (2) also resulted in a decrease in gastric myeloperoxidase activity increased by indomethacin. The gastroprotective effect of rhizonyl alcohol (2) can be attributed to its antioxidant properties and its suppressing effect on neutrophil infiltration into gastric tissues. |
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BM Sürdürülebilir Kalkınma Amaçları
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