The Effects of Methanol Extract of Lobaria pulmonaria a Lichen Species on Indometacin Induced Gastric Mucosal Damage Oxidative Stress and Neutrophil Infiltration
Yazarlar (8)
Başak Karakuş
Türkiye
Ahmet Çakır
Kilis 7 Aralık Üniversitesi, Türkiye
Zekai Halıcı
Atatürk Üniversitesi, Türkiye
Yasin Bayır
Atatürk Üniversitesi, Türkiye
Mesut Bünyami Halıcı
Atatürk Üniversitesi, Türkiye
Ali Aslan
Atatürk Üniversitesi, Türkiye
Halis Süleyman
Erzincan Üniversitesi, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | Phytotherapy Research | ||
| Dergi ISSN | 0951-418X Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI | ||
| Makale Dili | İngilizce | Basım Tarihi | 05-2009 |
| Cilt / Sayı / Sayfa | 23 / 5 / 635–639 | DOI | 10.1002/ptr.2675 |
| Makale Linki | http://doi.wiley.com/10.1002/ptr.2675 | ||
| Özet |
| AbstractLobaria pulmonaria, a lichen species, has been used in traditional medicine for the treatment of various diseases. This study was designed to determine the gastroprotective effect of the methanol extract of L. pulmonaria in an indometacin‐induced ulcer model in rats. The results showed that gastric lesions were significantly reduced in a dose‐dependent manner. Furthermore, the administration of indometacin caused a significant decrease in the levels of superoxide, glutathione peroxidase and reduced glutathione and an increase in the lipid peroxidation level. Administration of the lichen extract, however, produced an increase in the levels of these enzymes and a decrease in lipid peroxidation levels, although catalase and myeloperoxidase levels were unaffected. The present results suggested that Lobaria pulmonaria has a gastroprotective effect, probably due to reducing oxidative stress and neutrophil infiltration. Copyright © 2008 John Wiley & Sons, Ltd. |
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