Alpha Lipoic Acid Protects against Indomethacin Induced Gastric Oxidative Toxicity by Modulating Antioxidant System
Yazarlar (8)
Kürşat Ali Kaplan
Türkiye
Zekai Halıcı
Atatürk Üniversitesi, Türkiye
Mesut Bünyami Halıcı
Atatürk Üniversitesi, Türkiye
Elif Çadırcı
Atatürk Üniversitesi, Türkiye
Özlem Aydın Berktaş
Atatürk Üniversitesi, Türkiye
Ahmet Çakır
Kilis 7 Aralık Üniversitesi, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | Journal of Food Science | ||
| Dergi ISSN | 0022-1147 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI | ||
| Makale Dili | İngilizce | Basım Tarihi | 11-2012 |
| Cilt / Sayı / Sayfa | 77 / 11 / 224–230 | DOI | 10.1111/j.1750-3841.2012.02920.x |
| Makale Linki | http://doi.wiley.com/10.1111/j.1750-3841.2012.02920.x | ||
| Özet |
| Abstract: Gastroprotective effects of α‐lipoic acid (ALA) against oxidative gastric damage induced by indomethacin (IND) have been investigated. All doses (50, 75, 100, 150, 200, and 300 mg/kg body weight) of ALA reduced the ulcer index with 88.2% to 96.1% inhibition ratio. In biochemical analyses of stomach tissues, ALA administration decreased the level of lipid peroxidation (LPO) and activities of myeloperoxidase (MPO) and catalase (CAT) in gastric tissues, which were increased after IND application. ALA also increased the level of glutathione (GSH) and activities of superoxide dismutase (SOD) and glutathione S‐transferase (GST) that were decreased in gastric damaged stomach tissues. In conclusion, the gastroprotective effect of ALA could be attributed to its ameliorating effect on the antioxidant defense systems. |
| Anahtar Kelimeler |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları |