The role of erythropoietin in the protection of gastric mucosa from indometacin induced gastric injury and its relationship with oxidant and antioxidant parameters in rats
Yazarlar (11)
Fatih Albayrak
Atatürk Üniversitesi, Türkiye
Zekai Halıcı
Atatürk Üniversitesi, Türkiye
Beyzagül Polat
Atatürk Üniversitesi, Türkiye
Hakan Dursun
Atatürk Üniversitesi, Türkiye
Abdullah Uyanık
Atatürk Üniversitesi, Türkiye
Yasin Bayır
Atatürk Üniversitesi, Türkiye
Feride Koç
Erciyes Üniversitesi, Türkiye
Halis Süleyman
Erzincan Üniversitesi, Türkiye
Yavuz Albayrak
Türkiye
Mehmet Ali Güngör
Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | Journal of Pharmacy and Pharmacology | ||
| Dergi ISSN | 0022-3573 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI | ||
| Makale Dili | İngilizce | Basım Tarihi | 01-2010 |
| Cilt / Sayı / Sayfa | 62 / 1 / 85–90 | DOI | 10.1211/jpp.62.01.0009 |
| Makale Linki | http://doi.wiley.com/10.1211/jpp.62.01.0009 | ||
| Özet |
| Abstract Objectives Erythropoietin has anti-oxidative and anti-inflammatory activity. We wanted to evaluate its activity in preventing damage to the gastric mucosa. Methods We examined the protective effect of erythropoietin on indometacin-induced gastric mucosa damage in the rat stomach and compared its potency with that of famotidine. We also measured effects on oxidant and antioxidant parameters in the rat stomach. Key findings Famotidine and erythropoietin 2500 and 5000 IU/kg reduced the ulcer area by 98%, 31% and 58%, respectively, compared with the indometacin group. Superoxide dismutase activity and glutathione level were decreased and myeloperoxidase activity increased in the indometacin group compared with healthy rats. Famotidine and erythropoietin at all doses increased superoxide dismutase and glutathione levels significantly compared with the indometacin group. Myeloperoxidase activity was decreased by erythropoietin and famotidine. Conclusions These results support the view that erythropoietin counteracts the effects of indometacin in inducing gastric ulcer and could be used as a an antiulcer compound. Its antiulcer effect is less potent than that of famotidine. The antiulcerogenic effects of erythropoietin may be related to its intrinsic ability to sustain the activities of free-radical scavenging enzymes and the bioavailability of glutathione. |
| Anahtar Kelimeler |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları |