Relationship between Oxidative Stress and Cardiomyopathic Changes in Ovariectomized Rats
Yazarlar (10)
Enbiya Aksakal
Atatürk Üniversitesi, Türkiye
Nurhan Akaras
Atatürk Üniversitesi, Türkiye
İbrahim Halil Tanboğa
Atatürk Üniversitesi, Türkiye
Mustafa Kurt
Mustafa Kemal Üniversitesi, Türkiye
Zekai Halıcı
Atatürk Üniversitesi, Türkiye
Bünyami Ünal
Atatürk Üniversitesi, Türkiye
Ali Alkan
Türkiye
Berrin Özkılıç
Türkiye
Ülgen Aytan
Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | Cardiology | ||
| Dergi ISSN | 1421-9751 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI | ||
| Makale Dili | İngilizce | Basım Tarihi | 01-2011 |
| Cilt / Sayı / Sayfa | 119 / 4 / 235–241 | DOI | 10.1159/000333003 |
| Makale Linki | http://www.karger.com/doi/10.1159/000333003 | ||
| Özet |
| Objectives: Menopause has a negative effect on cardiovascular functions. However, very little is known of the overall effect of menopause on the cardiac ultrastructure or the pathophysiological basis of this. Methods: A group of 12-week-old female Sprague Dawley rats were randomly allocated to healthy control (n = 6) and ovariectomy groups (n = 6). Twelve weeks after ovariectomy, the rats’ cardiac tissues were histopathologically analyzed for determination of oxidant and antioxidant enzymes [activities of catalase (CAT), superoxide dismutase (SOD), and myeloperoxidase (MPO) and amount of glutathione (GSH) and lipid peroxidation (LPO)]. Results: When compared to the control group, the ovariectomy group showed cardiomyopathic changes. In tissue, activities of CAT (185 ± 2.4 vs. 112 ± 1.4 mmol/min/mg tissue; p < 0.05), SOD (153 ± 1.0 vs. 146 ± 0.7 mmol/min/mg tissue; p < 0.05) and MPO (19 ± 0.8 vs. 8.6 ± 0.11 µmol/min/mg tissue; p < 0.05) and LPO levels (32.1 ± 0.77 vs. 14.4 ± 0.20 nmol/g tissue; p < 0.05) were significantly increased in the ovariectomy group when compared to the control group. However, GSH levels (3.43 ± 0.02 vs. 3.73 ± 0.01 nmol/g tissue; p < 0.05) were significantly lower in the ovariectomy group when compared to the control group. Conclusion: Using an experimental animal model, we were able to demonstrate that menopause causes cardiomyopathic changes, and we propose that these changes could be mediated by oxidative stress. |
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BM Sürdürülebilir Kalkınma Amaçları
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