Understanding the relationship between lung GABAA receptors and aquaporin-1: a new therapeutic approach for acute lung injury
Yazarlar (6)
Dr. Öğr. Üyesi Hamza Halıcı Türkiye
Zeynep Karaköy Kaya Türkiye
Prof. Dr. Elif Çadırcı Türkiye
Prof. Dr. Zekai Halıcı Türkiye
Dr. Öğr. Üyesi Bengül ÖZDEMİR SARIKAYA Kafkas Üniversitesi, Türkiye
Doç. Dr. Erdem TOKTAY Kafkas Üniversitesi, Türkiye
| Makale Türü |
Özgün Makale
(SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale)
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| Dergi Adı | BMC Pulmonary Medicine (Q2) | ||
| Dergi ISSN | 1471-2466 Dergi Bilgileri (2026) | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 04-2026 |
| Cilt / Sayı / Sayfa | – / 0 / – | DOI | 10.1186/s12890-026-04301-3 |
| Makale Linki | https://doi.org/10.1186/s12890-026-04301-3 | ||
| UAK Araştırma Alanları |
Sağlık Bilimleri
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| Özet |
| BACKGROUND: This study aimed to investigate the effects of the GABAA receptor and the potential relationship between GABA/ GABAA receptor signalling and aquaporin-1 in acute lung injury (ALI). METHODS: Fifty-six male Wistar albino rats (220–240 g) were divided into seven groups. Two groups received intraperitoneal diazepam at 5 or 10 mg/kg. In two other groups, 0.1 mg/kg flumazenil was administered five minutes after diazepam. Thirty minutes after the final treatment, all groups except the healthy controls were subjected to an LPS- induced ALI model. Lung tissue were collected 24 h after LPS administration and analysed using histopathological, molecular, and biochemical methods. RESULTS: In the present study, it was found that aquaporin-1, which plays an important regulatory role in LPS-damaged lung tissue, decreased and the weight of lung tissue increased in wet/dry analysis of a murine model of ALI. The levels of IL-1β, IL-6, and TNF-α were found to be elevated. Additionally, in groups treated with the GABAA receptor modulator diazepam, the levels of these inflammatory cytokines were significantly reduced and in parallel a significant increase in aquaporin-1 expression was observed. CONCLUSION: Diazepam, acting as a GABAA receptor modulator, may alleviate ALI by reducing inflammation and enhancing aquaporin-1 expression via GABAA receptor activation. |
| Anahtar Kelimeler |
| Acute lung injury | Aquaporin-1 | Diazepam | GABAA |
BM Sürdürülebilir Kalkınma Amaçları
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| Yöksis | 1 |
| PubMed | 1 |