Multiple Reassortments, Limited Geographic Spread, and Comparable Pathogenicity of Crimean‐Congo Hemorrhagic Fever Viruses in Sivas Province, Türkiye
 
Yazarlar (16)
Qianying Lin
Los Alamos National Laboratory, Amerika Birleşik Devletleri
Prof. Dr. Nazif Elaldi Cumhuriyet Üniversitesi, Türkiye
Arş. Gör. Mesut YİĞİT Kafkas Üniversitesi, Türkiye
Dr. Öğr. Üyesi Baris Yildiz Kafkas Üniversitesi, Türkiye
Roger Hewson
Uk Health Security Agency, İngiltere
Martin Lopez-Garcia
University of Leeds, İngiltere
Grant Lythe
University of Leeds, İngiltere
Öğr. Gör. Ayse Nur Pektas Cumhuriyet Üniversitesi, Türkiye
Doç. Dr. Binnur Koksal Cumhuriyet Üniversitesi, Türkiye
Tuba Nur Tasseten
Cumhuriyet Üniversitesi, Türkiye
Ahmet Deniz Kafkas Üniversitesi, Türkiye
Hilal Bedir
Kafkas Üniversitesi, Türkiye
Dr. Öğr. Üyesi Yasemin Cakir Kiymaz Cumhuriyet Üniversitesi, Türkiye
Prof. Dr. Zati VATANSEVER Kafkas Üniversitesi, Türkiye
Carmen Molina-Paris
Los Alamos National Laboratory, Amerika Birleşik Devletleri
Thomas Leitner
Los Alamos National Laboratory, Amerika Birleşik Devletleri
Makale Türü Açık Erişim Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale)
Dergi Adı Journal of Medical Virology (Q1)
Dergi ISSN 0146-6615 Dergi Bilgileri (2026)
Dergi Tarandığı Indeksler SCI-Expanded
Makale Dili İngilizce Basım Tarihi 06-2026
Cilt / Sayı / Sayfa 98 / 6 / – DOI 10.1002/jmv.71027
Makale Linki https://doi.org/10.1002/jmv.71027
UAK Araştırma Alanları
Veteriner Parazitolojisi
Özet
Crimean-Congo hemorrhagic fever virus (CCHFV) is a segmented RNA virus that can cause severe hemorrhagic fever and is primarily transmitted to humans and other mammals through tick bites. Since segment reassortment can increase genetic diversity and disease severity, we sampled infected ticks and humans in Sivas Province, Türkiye, a region with high CCHFV prevalence. Analysis of 113 human and 23 Hyalomma tick CCHFV samples revealed three main phylogenetic clades in Sivas. The most common clade (SIVAS-2) was involved in multiple reassortants. Phylogenetic analysis indicated multiple independent reassortment events involving all three CCHFV genome segments. The most common reassortant (1.1.2) was detected only in the Zara district of Sivas in both humans and ticks. We found that most infections were geographically limited to local spread and that infections with more than one variant …
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