Novel Benzoic Acid Derivatives Bearing Quinazolin‐4(3H)‐one Ring: Synthesis, Characterization, and Inhibition Effects on α‐Glucosidase and α‐Amylase
Yazarlar (1)
Doç. Dr. Feyzi Sinan TOKALI Kafkas Üniversitesi, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | Chemistryselect (Q3) | ||
| Dergi ISSN | 2365-6549 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 12-2022 |
| Cilt / Sayı / Sayfa | 7 / 48 / – | DOI | 10.1002/slct.202204019 |
| Makale Linki | http://dx.doi.org/10.1002/slct.202204019 | ||
| UAK Araştırma Alanları |
Organik Kimya
Spektroskopi
Biyokimya
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| Özet |
| In this study, new benzoic acid derivatives of the quinazolinone ring, which is one of the biologically active members of nitrogen‐containing heterocyclic compounds, were synthesized with excellent yields (98–90 %). The structures of the novel compounds (1–12) were characterized with Fourier‐transform Infrared (FTIR), Nuclear Magnetic Resonance (1H NMR–13C NMR), and High‐Resolution Mass Spectroscopy (HRMS). α‐Glucosidase and α‐Amylase inhibition properties were examined to evaluate the anti‐diabetic properties of the synthesized compounds. For α‐Glucosidase, molecules showed IC50 in ranging of >100–3.468±0.270 μM and Kis in ranging of >100–3.310±0.326 μM. For α‐Amylase, molecules showed IC50 in ranging of >100–1.215±0.225 μM. 4‐[(2‐[(4‐phenylpiperazin‐1‐yl)methyl]‐4‐oxoquinazolin‐3(4H)‐ylimino)methyl]benzoicacid (10) has the strongest inhibitory effect for both … |
| Anahtar Kelimeler |
| Diabetes | Quinazolin-4(3H)-one | α-Amylase | α-Glucosidase, Inhibition |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Web of Science | 41 |
| Scopus | 29 |
| Google Scholar | 41 |