Carboxylate‐ and Sulfonate‐Containing Quinazolin‐4(3H)‐one Rings: Synthesis, Characterization, and Carbonic Anhydrase I–II and Acetylcholinesterase Inhibition Properties
Yazarlar (3)
Doç. Dr. Feyzi Sinan TOKALI Kafkas Üniversitesi, Türkiye
Zuhal Alım Kırşehir Ahi Evran Üniversitesi, Türkiye
Doç. Dr. Ümit Yırtıcı Kirikkale Üniversitesi, Türkiye
| Makale Türü |
Özgün Makale
(SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale)
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| Dergi Adı | Chemistryselect (Q3) | ||
| Dergi ISSN | 2365-6549 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 02-2023 |
| Cilt / Sayı / Sayfa | 8 / 8 / – | DOI | 10.1002/slct.202204191 |
| Makale Linki | http://dx.doi.org/10.1002/slct.202204191 | ||
| UAK Araştırma Alanları |
Organik Kimya
Spektroskopi
Biyokimya
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| Özet |
| Quinazolines are a group of bioactive heterocyclic compounds with a wide range of biological activities and have gained an important place in the design of active drugs with various targets due to their pharmacological properties. Carbonic anhydrase (CA) and acetylcholinesterase (AChE) inhibitors are very important pharmacologically. In this study, inhibition effects of newly synthesized quinazolin‐4(3H)‐one derivatives on human erythrocyte CA‐I (hCA‐I) and CA‐II (hCA‐II) isoenzyme and AChE activity were investigated. The structures of the novel compounds were characterized by fourier‐transform infrared (FTIR), nuclear magnetic resonance (NMR), and high‐resolution mass spectroscopy (HRMS). All molecules showed strong inhibitory effect in all three enzymes. 4‐[(4‐Oxo‐2‐(phenoxymethyl)quinazolin‐3(4H)‐ylimino)methyl]phenyl furan‐2‐carboxylate for hCA‐I (IC50: 205 nM), 4‐[(4‐oxo‐2 … |
| Anahtar Kelimeler |
| Acetylcholinesterase | carbonic anhydrase | docking | inhibition | quinazolin-4(3H)-one | Schiff base |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Web of Science | 32 |
| Scopus | 34 |
| Google Scholar | 35 |