New Diacetic Acids Containing Quinazolin-4(3H)-one: Synthesis, Characterization, Anticholinergic Properties, DFT Analysis and Molecular Docking Studies
Yazarlar (5)
Doç. Dr. Feyzi Sinan TOKALI Kafkas Üniversitesi, Türkiye
Dr. Öğr. Üyesi Rüya Sağlamtaş Aǧrı İbrahim Çeçen Üniversitesi, Türkiye
Doç. Dr. Aykut Öztekin Aǧrı İbrahim Çeçen Üniversitesi, Türkiye
Doç. Dr. Ümit Yırtıcı Kirikkale Üniversitesi, Türkiye
Prof. Dr. Veysel Çomaklı Aǧrı İbrahim Çeçen Üniversitesi, Türkiye
| Makale Türü |
Özgün Makale
(SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale)
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| Dergi Adı | Chemistryselect (Q3) | ||
| Dergi ISSN | 2365-6549 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 03-2023 |
| Cilt / Sayı / Sayfa | 8 / 10 / – | DOI | 10.1002/slct.202205039 |
| Makale Linki | https://doi.org/10.1002/slct.202205039 | ||
| UAK Araştırma Alanları |
Organik Kimya
Spektroskopi
Biyokimya
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| Özet |
| In this study, a new series of quinazolin‐4(3H)‐ones, which constitute an important part of biologically active heterocyclic compounds, were synthesized with excellent yields (99‐94 %). The structures of the synthesized compounds (1–14) were characterized with Fourier‐transform infrared (FTIR), nuclear magnetic resonance (1H NMR – 13C NMR), and high‐resolution mass spectroscopy (HRMS). Acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibition properties were examined to evaluate the anticholinergic properties of the synthesized compounds. For AChE, molecules showed IC50 in ranging of 16.27–9.12 μM and Kis in ranging of 19.20±0.68–4.83±0.19 μM. For BChE, molecules showed IC50 in ranging of 16.77–8.50 μM and Kis in ranging of 10.35±2.15–3.38±0.25 μM. Molecular docking was performed to determine the predicted interactions between the synthesized molecules and … |
| Anahtar Kelimeler |
| Acetylcholinesterase | butyrylcholinesterase | DFT | inhibition | quinazolin-4(3H)-one |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Web of Science | 22 |
| Scopus | 21 |
| Google Scholar | 24 |